毒理学数据:
1.急性毒性
LD50:9600mg/kg(大鼠经口)
LC50:17000ppm(大鼠吸入,4h)
2.刺激性
家兔经皮:20mg(24h),中度刺激。
家兔经眼:100mg,轻度刺激。
3.亚急性与慢性毒性 豚鼠吸入5.46g/m3,每天3h,3个月,肝重增加,有脂肪变性,肺炎。
4.致突变性 微生物致突变:鼠伤寒沙门菌10μg/皿。DNA修复:大肠杆菌500mg/L。基因转化和有丝分裂重组:酿酒酵母5350mg/L。细胞遗传学分析:仓鼠卵巢160mg/L。
5.致畸性 大鼠孕后1~22d经口给予最低中毒剂量(TDLo)43mg/kg,致心血管系统发育畸形。
6.致癌性 IARC致癌性评论:G3,对人及动物致癌性证据不足。
生态学数据:
1.生态毒性
LC50:42.3~105mg/L(96h)(黑头呆鱼);73mg/L(48h)(青鳉)
2.生物降解性
好氧生物降解(h):3360~6552
厌氧生物降解(h):13440~26208
生物降解-二次沉降处理(h):220~250
3.非生物降解性
空气中光氧化半衰期(h):5393~53929
一级水解半衰期(h):0.73
4.其他有害作用 该物质对环境有危害,应特别注意对地下水的污染。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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KJ2975000
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CHEMICAL NAME :
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Ethane, 1,1,1-trichloro-
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CAS REGISTRY NUMBER :
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71-55-6
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BEILSTEIN REFERENCE NO. :
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1731614
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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89
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MOLECULAR FORMULA :
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C2-H3-Cl3
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MOLECULAR WEIGHT :
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133.40
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WISWESSER LINE NOTATION :
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GXGG1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Human - man
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TYPE OF TEST :
-
Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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350 ppm
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TOXIC EFFECTS :
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Behavioral - hallucinations, distorted perceptions Behavioral - changes in motor activity (specific assay) Behavioral - changes in psychophysiological tests
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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670 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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920 ppm/70M
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TOXIC EFFECTS :
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Behavioral - changes in motor activity (specific assay) Sense Organs and Special Senses (Eye) - conjunctive irritation
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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200 ppm/4H
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TOXIC EFFECTS :
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Behavioral - changes in motor activity (specific assay) Behavioral - irritability
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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9600 mg/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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18000 ppm/4H
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3593 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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6 gm/kg
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TOXIC EFFECTS :
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Cardiac - pulse rate Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
-
3911 ppm/2H
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TOXIC EFFECTS :
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Behavioral - excitement
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2568 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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16 gm/kg
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TOXIC EFFECTS :
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Behavioral - sleep Behavioral - ataxia
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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750 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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3100 mg/kg
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TOXIC EFFECTS :
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Liver - liver function tests impaired
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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95 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LC - Lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Primate - monkey
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DOSE/DURATION :
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>5000 ppm/7H
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TOXIC EFFECTS :
-
Behavioral - tremor Behavioral - ataxia
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TYPE OF TEST :
-
LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
-
24400 mg/m3
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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5660 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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15800 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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9470 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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10000 ppm/1H/13W-I
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TOXIC EFFECTS :
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Liver - other changes
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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1000 ppm/1H/13W-I
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TOXIC EFFECTS :
-
Liver - other changes
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TYPE OF TEST :
-
TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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3000 ppm/7H/29D-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
-
Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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650 ppm/7H/58D-I
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
-
Oral
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DOSE :
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43 mg/kg
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SEX/DURATION :
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female 1-22 day(s) after conception lactating female 21 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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2100 ppm/6H
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SEX/DURATION :
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female 1-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
MUTATION DATA
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TYPE OF TEST :
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Cytogenetic analysis
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TEST SYSTEM :
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Rodent - hamster Ovary
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 2460 mg/m3 (450 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 1910 mg/m3 (350 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,515,1979 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,515,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 18,365,1974 TOXICOLOGY REVIEW EATR** U.S. Army, Edgewood Arsenal Technical Report. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: EB-TR-75047 TOXICOLOGY REVIEW AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 40(3),A46,1979 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 350 ppm (1900 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,161,1971 OSHA PEL (Gen Indu):8H TWA 350 ppm (1900 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 350 ppm (1900 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 350 ppm (1900 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 350 ppm (1900 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 125 ppm (680 mg/m3) JAN 1993 OEL-BELGIUM:TWA 350 ppm (1910 mg/m3);STEL 450 ppm (2460 mg/m3) JAN 1993 OEL-DENMARK:TWA 100 ppm (540 mg/m3) JAN 1993 OEL-FINLAND:TWA 100 ppm (540 mg/m3);STEL 250 ppm (1400 mg/m3) JAN 1993 OEL-FRANCE:TWA 300 ppm (1650 mg/m3);STEL 450 ppm (2500 mg/m3) JAN 1993 OEL-GERMANY:TWA 200 ppm (1080 mg/m3) JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 300 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 200 ppm (1100 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 200 ppm (1080 mg/m3);STEL 500 ppm JAN 1993 OEL-THE PHILIPPINES:TWA 350 ppm (1900 mg/m3) JAN 1993 OEL-RUSSIA:TWA 200 ppm;STEL 20 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (300 mg/m3);STEL 90 ppm (500 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 200 ppm (1080 mg/m3);STEL 1000 ppm JAN 1993 OEL-TURKEY:TWA 350 ppm (1900 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 350 ppm (1900 mg/m3);STEL 450 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,1,1-TRICHLOROETHANE-air:CL 350 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46970 No. of Facilities: 109850 (estimated) No. of Industries: 412 No. of Occupations: 205 No. of Employees: 1511801 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46970 No. of Facilities: 120527 (estimated) No. of Industries: 417 No. of Occupations: 243 No. of Employees: 2528300 (estimated) No. of Female Employees: 762399 (estimated)
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