568-75-2

• 常用中文名：7-hydroxymethyl-12-methylbenz(a)anthracene
• 常用英文名：7-hydroxymethyl-12-methylbenz(a)anthracene
• CAS号：568-75-2
• 分子式：C₂₀H₁₆O
• 分子量：272.34000
• 发布时间：2016-04-02 07:20:43
• 更新时间：2024-01-09 12:36:42

名称

• 英文名: (12-methylbenzo[a]anthracen-7-yl)methanol
• 英文别名: BENZ(a)ANTHRACENE-7-METHANOL,12-METHYL; [3H]-7-Hydroxymethyl-12-methylbenz[a]anthracene; 7-Hydroxymethyl-12-methylbenz<a>anthracen; 12-Hydroxymethyl-7-methylbenz<a>anthracen; 7-Hydroxymethyl-12-Dimethylbenzo<a>anthracene; 7-(Hydroxymethyl)-12-methylbenz(a)anthracene; 12-Methylbenz[a]anthracene-7-methanol

物化性质

• 密度: 1.227g/cm3
• 沸点: 523.8ºC at 760 mmHg
• 分子式: C₂₀H₁₆O
• 分子量: 272.34000
• 闪点: 225.9ºC
• 精确质量: 272.12000
• PSA: 20.23000
• LogP: 4.94690
• 折射率: 1.757

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CW8750000 CHEMICAL NAME : Benz(a)anthracene-7-methanol, 12-methyl- CAS REGISTRY NUMBER : 568-75-2 LAST UPDATED : 199709 DATA ITEMS CITED : 26 MOLECULAR FORMULA : C20-H16-O MOLECULAR WEIGHT : 272.36 WISWESSER LINE NOTATION : L D6 B666J C1 J1Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 73 mg/kg TOXIC EFFECTS : Blood - normocytic anemia Blood - granulocytopenia Blood - leukopenia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 150 mg/kg/39D-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - increased incidence of tumors in susceptible strains TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 16 mg/kg/17W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg/10W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 25 mg/kg SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 25 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 25 mg/kg SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - endocrine system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 25 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous DOSE : 25 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) TYPE OF TEST : DNA damage TYPE OF TEST : DNA adduct MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 50 gm/L REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 22,345,1978

合成路线

27018-50-4 ~% 568-75-2

文献：Flesher; Soedigdo; Kelley Journal of medicinal chemistry, 1967 , vol. 10, # 5 p. 932 - 936

57-97-6 ~% 568-75-2 2518-01-6

文献：Uibopuu, Kh. M.; Gubergritis, M. Ya.; Perin-Roussel, O.; Perin, F.; Jacquignon, P. S. J. Appl. Chem. USSR (Engl. Transl.), 1982 , vol. 55, # 11 p. 2519 - 2528,2277 - 2285

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