毒理学数据:
1、
试验方法： 口服
摄入剂量： 118毫克/千克
测试对象： 啮齿动物-鼠
毒性类型： 急性
毒性作用： 详细的毒副作用没有报告以外的其他致死剂量值
2、
试验方法： 皮下
摄入剂量： 178毫克/千克
测试对象： 啮齿动物-鼠
毒性类型： 急性
毒性作用： 详细毒副作用没有报告以外的其他致死剂量值
3、
试验方法： 静脉
摄入剂量： 20毫克/千克
测试对象： 啮齿动物-鼠
毒性类型： 急性
毒性作用： 1.肌肉收缩或痉挛
2.肺 ，胸部或呼吸-其他变化
4、
试验方法： 未报告
摄入剂量： 150毫克/千克
测试对象： 啮齿动物-鼠
毒性类型： 急性
毒性作用： 1.Details的毒副作用没有报告以外的其他致死剂量值
5、
试验方法： 口服
摄入剂量： 70毫克/千克
测试对象： 啮齿动物-鼠
毒性类型： 急性
毒性作用： 详细的毒副作用没有报告以外的其他致死剂量值
6 、
试验方法： 腹腔
摄入剂量： 39毫克/千克
测试对象： 啮齿动物-鼠
毒性类型： 急性
毒性作用： 详细的毒副作用没有报告以外的其他致死剂量值
7.急性毒性 LD50：118mg/kg（大鼠经口）
8.刺激性 暂无资料
9.致突变性基因转化与有丝分裂重组：酿酒酵母菌14mmol/L。
生态学数据:
1.生态毒性 LC50：＞76.9mg/L（48h）（青鳉）
2.生物降解性 暂无资料
3.非生物降解性 暂无资料
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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CQ8750000
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CHEMICAL NAME :
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Barium chloride
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CAS REGISTRY NUMBER :
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10361-37-2
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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51
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MOLECULAR FORMULA :
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Ba-Cl2
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MOLECULAR WEIGHT :
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208.24
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WISWESSER LINE NOTATION :
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BA G2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
-
118 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
-
Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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178 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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20 mg/kg
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TOXIC EFFECTS :
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Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Oral
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SPECIES OBSERVED :
-
Rodent - mouse
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DOSE/DURATION :
-
70 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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39 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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10 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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12 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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90 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
-
Mammal - dog
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DOSE/DURATION :
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10 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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18 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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40 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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170 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Subcutaneous
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SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
40 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
-
Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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15 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Parenteral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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20 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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76 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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55 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Amphibian - frog
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DOSE/DURATION :
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910 mg/kg
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TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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398 mg/kg
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TOXIC EFFECTS :
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Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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91 mg/kg/26W-I
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TOXIC EFFECTS :
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Behavioral - alteration of classical conditioning Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - multiple enzyme effects
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3 gm/kg/10D-I
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TOXIC EFFECTS :
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Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death Related to Chronic Data - changes in ovarian weight
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intratesticular
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DOSE :
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16659 ug/kg
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SEX/DURATION :
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male 1 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - testes, epididymis, sperm duct
MUTATION DATA
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TYPE OF TEST :
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Gene conversion and mitotic recombination
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TEST SYSTEM :
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Yeast - Saccharomyces cerevisiae
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DOSE/DURATION :
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14 mmol/L
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REFERENCE :
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MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 1,21,1986 *** REVIEWS *** ACGIH TLV-TWA 0.5 mg(Ba)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ. Volume(issue)/page/year: 7,313,1942 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(Ba)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,21,1971 OSHA PEL (Gen Indu):8H TWA 0.5 mg(Ba)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 mg(Ba)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 mg(Ba)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 mg(Ba)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-AUSTRIA:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-BELGIUM:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-DENMARK:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-FINLAND:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-GERMANY:TWA 0.5 mg(Ba)/m3 (total dust) JAN 1993 OEL-HUNGARY:STEL 0.5 mg(Ba)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-POLAND:TWA 0.5 mg(Ba)/m3;STEL 1.5 mg(Ba)/m3 JAN 1993 OEL-RUSSIA:STEL 0.3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.5 mg(Ba)/m3;STEL 1 mg(Ba)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.5 mg(Ba)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 08650 No. of Facilities: 1971 (estimated) No. of Industries: 46 No. of Occupations: 30 No. of Employees: 13339 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 08650 No. of Facilities: 4299 (estimated) No. of Industries: 62 No. of Occupations: 62 No. of Employees: 57997 (estimated) No. of Female Employees: 15249 (estimated)
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