2673269-81-1

2673269-81-1结构式

中文名	雷米普利-d3
英文名	Ramipril-d3

描述	雷米普利-d3是氘标记的雷米普利[1]。雷米普利(HOE-498)是一种血管紧张素转换酶(ACE)抑制剂,其IC50为5nM。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)
体外研究	氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Raasch, W., et al., Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR. J Hypertens, 2004. 22(3): p. 611-8. [3]. Stevens, B.R., M.I. Phillips, and A. Fernandez, Ramipril inhibition of rabbit (Oryctolagus cuniculus) small intestinal brush border membrane angiotensin converting enzyme. Comp Biochem Physiol C, 1988. 91(2): p. 493-7. [4]. Kohlstedt, K., et al., Angiotensin-converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res, 2004. 94(1): p. 60-7. [5]. Ceconi, C., et al., Differences in the effect of angiotensin-converting enzyme inhibitors on the rate of endothelial cell apoptosis: in vitro and in vivo studies. Cardiovasc Drugs Ther, 2007. 21(6): p. 423-9.

分子式	C₂₃H₂₉D₃N₂O₅
分子量	419.53