5967-73-7

• 常用中文名：(R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵
• 常用英文名：(6R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride (1: 1)
• CAS号：5967-73-7
• 分子式：C₂₁H₂₈ClNO
• 分子量：345.90600
• 发布时间：2018-08-02 11:14:11
• 更新时间：2024-01-23 18:31:25

名称

• 中文名: (R)-二甲基(1-甲基-4-氧代-3,3-二苯基己基)氯化铵
• 英文名: (6R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone hydrochloride (1: 1)
• 英文别名: (-)-Mephobarbital; (R)-(6-dimethylamino-4,4-diphenylheptan-3-one) hydrochloride; UNII-5NC67NU76B component ALARQZQTBTVLJV-CYBMUJFWSA-N; (R)-6-dimethylamino-4,4-diphenyl-3-heptanone hydrochloride; (-)-Methylphenobarbital; (-)-Methadone hydrochloride; (6R)-methadone hydrochloride; (R)-Methylphenobarbital; (5S)-mephobarbital; 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-,(R); (R)-(-)-mephobarbital; R-(-)-methadone hydrochloride

物化性质

• 沸点: 423.7ºC at 760 mmHg
• 熔点: 220-227ºC
• 分子式: C₂₁H₂₈ClNO
• 分子量: 345.90600
• 闪点: 126.5ºC
• 精确质量: 345.18600
• PSA: 20.31000
• LogP: 5.09400

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MJ6475000 CHEMICAL NAME : 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (-)- CAS REGISTRY NUMBER : 5967-73-7 LAST UPDATED : 199601 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C21-H27-N-O.Cl-H MOLECULAR WEIGHT : 345.95 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 44 ug/kg TOXIC EFFECTS : Behavioral - hallucinations, distorted perceptions Behavioral - analgesia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,282,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 24 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 98,305,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Endocrine - other changes REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 10,260,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 97300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOCEAH Journal of Organic Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1936- Volume(issue)/page/year: 17,321,1952 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 98,305,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 19 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 98,305,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18 mg/kg TOXIC EFFECTS : Behavioral - analgesia REFERENCE : APACAB Acta Physiologica Academiae Scientiarum Hungaricae. (Budapest, Hungary) V.1-60, 1950-82. Volume(issue)/page/year: 4,363,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6483 ug/kg TOXIC EFFECTS : Behavioral - analgesia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 145,11,1964

合成路线

7576-16-1 925-90-6 ~42% 5967-73-7

文献：Hull, Jonathan D.; Scheinmann, Feodor; Turner, Nicholas J. Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 567 - 576

1095-90-5 ~% 15284-15-8 5967-73-7

文献：Somberg, John Charin; Ranade, Vasant V. Patent: US2010/10096 A1, 2010 ; Location in patent: Page/Page column 1 ;

86-29-3 ~% 5967-73-7

文献：Hull, Jonathan D.; Scheinmann, Feodor; Turner, Nicholas J. Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 567 - 576

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