936727-93-4

• 常用中文名：1-(4-Trifluoromethoxyphenyl)-1-carboxycyclopropane
• 常用英文名：1-(4-Trifluoromethoxyphenyl)-1-carboxycyclopropane
• CAS号：936727-93-4
• 分子式：C₁₁H₉F₃O₃
• 分子量：246.183
• 发布时间：2016-12-24 14:10:41
• 更新时间：2024-01-09 18:27:01

名称

• 英文名: 1-[4-(trifluoromethoxy)phenyl]cyclopropane-1-carboxylic acid
• 英文别名: 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid; 1-[4-(Trifluoromethoxy)phenyl]cyclopropanecarboxylic acid; y4765; Cyclopropanecarboxylic acid, 1-[4-(trifluoromethoxy)phenyl]-; 1-(4-Trifluoromethoxyphenyl)-1-carboxycyclopropane

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 304.1±42.0 °C at 760 mmHg
• 分子式: C₁₁H₉F₃O₃
• 分子量: 246.183
• 闪点: 137.7±27.9 °C
• 精确质量: 246.050385
• PSA: 46.53000
• LogP: 2.50
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.522

合成路线

952444-05-2 ~% 936727-93-4

文献：Taisho Pharmaceutical Co. Ltd.; Nissan Chemical Industries, Ltd. Patent: EP2003131 A1, 2008 ; Location in patent: Page/Page column 76 ; EP 2003131 A1

49561-96-8 ~% 936727-93-4

文献：Richards, Steven; Larson, Christopher J.; Koltun, Elena S.; Hanel, Art; Chan, Vicky; Nachtigall, Jason; Harrison, Amanda; Aay, Naing; Du, Hongwang; Arcalas, Arlyn; Galan, Adam; Zhang, Jeff; Zhang, Wentao; Won, Kwang-Ai; Tam, Danny; Qian, Fawn; Wang, Tao; Finn, Patricia; Ogilvie, Kathy; Rosen, Jon; Aoyama, Ron; Plonowski, Artur; Cancilla, Belinda; Bentzien, Frauke; Yakes, Michael; Mohan, Raju; Lamb, Peter; Nuss, John; Kearney, Patrick Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4322 - 4335