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2425-06-1

2425-06-1结构式
2425-06-1结构式
  • 常用中文名:敌菌丹
  • 常用英文名:Captafol
  • CAS号:2425-06-1
  • 分子式:C10H9Cl4NO2S
  • 分子量:349.061
  • 相关类别: 化学农药原药 杀菌剂 其他杀菌剂
  • 发布时间:2018-07-26 16:18:35
  • 更新时间:2024-01-10 08:54:48
  • 用来防治番茄叶和果实的病害、马铃薯枯萎病等。制剂有80%可湿性粉剂和40%悬浮剂。


化源商城直购

中文名 敌菌丹
英文名 captafol
中文别名 N-(1,1,2,2,-四氯乙硫基)-4-环已烯-1,2-二甲酰亚胺
四氯丹
英文别名 3a,4,7,7a-tetrahydro-N-(1,1,2,2-tetrachloroethanesulfenyl)phthalimide
FOLTAF
Captatol
2-(1,1,2,2-tetrachloro-ethylsulfanyl)-3a,4,7,7a-tetrahydro-isoindole-1,3-dione
haipen
EINECS 219-363-3
N-(1,1,2,2-tetrachloroethylthio)-1,2,3,6-tetrahydrophthalimide
N-(1,1,2,2-tetrachloroethylthio)cyclohex-4-ene-1,2-dicarboximide
Sanspor
cs5623
2-[(1,1,2,2-Tetrachloroethyl)sulfanyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione
Difosan
3a,4,7,7a-tetrahydro-2-[(1,1,2,2-tetrachloroethyl)thio]-1H-isoindole-1,3(2H)-dione
Captofol
1H-Isoindole-1,3(2H)-dione, 3a,4,7,7a-tetrahydro-2-[(1,1,2,2-tetrachloroethyl)thio]-
MFCD00041816
Folcid
3a,4,7,7a-Tetrahydro-2-((1,1,2,2-tetrachloroethyl)thio)-1H-isoindole-1,3(2H)-dione (9CI)
Captafol
kenofol
密度 1.6±0.1 g/cm3
沸点 365.7±52.0 °C at 760 mmHg
熔点 160-161°
分子式 C10H9Cl4NO2S
分子量 349.061
闪点 175.0±30.7 °C
精确质量 346.910797
PSA 62.68000
LogP 2.40
蒸汽压 0.0±0.8 mmHg at 25°C
折射率 1.629
储存条件

密封保存

稳定性

常温常压下稳定酸性和碱性条件下不稳定,在熔点温度时缓慢分解

分子结构

1、 摩尔折射率:75.57

2、 摩尔体积(m3/mol):212.7

3、 等张比容(90.2K):594.0

4、 表面张力(dyne/cm):60.7

5、 极化率(10 -24cm 3):29.96

计算化学

1、 疏水参数计算参考值(XlogP):3.8

2、 氢键供体数量:0

3、 氢键受体数量:2

4、 可旋转化学键数量:3

5、 互变异构体数量:3

6、 拓扑分子极性表面积(TPSA):37.4

7、 重原子数量:18

8、 表面电荷:0

9、 复杂度:387

10、同位素原子数量:0

11、确定原子立构中心数量:0

12、不确定原子立构中心数量:2

13、确定化学键立构中心数量:0

14、不确定化学键立构中心数量:0

15、共价键单元数量:1

更多

1. 性状:无色结晶固体

2. 密度(g/mL, ,25℃):未确定

3. 相对蒸汽密度(g/mL,空气=1):未确定

4. 熔点(ºC):160-161

5. 沸点(ºC,常压):未确定

6. 沸点(ºC 5mmHg):未确定

7. 折射率(nD20):未确定

8. 闪点(ºC):未确定

9. 比旋光度():未确定

10. 自燃点或引燃温度(ºC):未确定

11. 蒸气压(Pa,20ºC):未确定

12. 饱和蒸气压(kPa, 0ºC):未确定

13. 燃烧热(KJ/mol):未确定

14. 临界温度(ºC):未确定

15. 临界压力(KPa):未确定

16. 油水(辛醇/水)分配系数的对数值:未确定

17. 爆炸上限(%,V/V):未确定

18. 爆炸下限(%,V/V):未确定

19. 溶解性:难溶于水(1.4mg/L),微溶于大多数有机溶剂。

生态学数据:

1、其它有害作用:该物质对环境可能有危害,对水体应给予特别注意。

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GW4900000
CHEMICAL NAME :
4-Cyclohexene-1,2-dicarboximide, N-((1,1,2,2-tetrachloroethyl)thio)-
CAS REGISTRY NUMBER :
2425-06-1
BEILSTEIN REFERENCE NO. :
1543712
LAST UPDATED :
199712
DATA ITEMS CITED :
53
MOLECULAR FORMULA :
C10-H9-Cl4-N-O2-S
MOLECULAR WEIGHT :
349.06
WISWESSER LINE NOTATION :
T56 BVNV GUTJ CSXGGYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
15400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45360 mg/kg/12W-C
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
65520 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60480 mg/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15120 mg/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Cardiac - tumors Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
11 gm/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
250 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
500 mg/kg
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
975 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
200 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
400 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
Morphological transformation
TYPE OF TEST :
Dominant lethal test

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 78,177,1980 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.1 mg/m3 (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,353,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,353,1991 IARC Cancer Review:Group 2A IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,353,1991 TOXICOLOGY REVIEW MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 32,3,1975 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 mg/m3 JAN 1993 OEL-BELGIUM:TWA 0.1 mg/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg/m3 JAN 1993 OEL-FRANCE:TWA 0.1 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg/m3;Skin JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CAPTAFOL-air:10H CA TWA 0.1 mg/m3 (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2985 No. of Facilities: 59 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 117 (estimated)

符号 GHS07 GHS08 GHS09
GHS07, GHS08, GHS09
信号词 Danger
危害声明 H317-H350-H410
警示性声明 P201-P273-P280-P308 + P313-P501
个人防护装备 Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
危害码 (欧洲) T,N
风险声明 (欧洲) 45-43-50/53
安全声明 (欧洲) S45;S53;S60;S61
危险品运输编码 UN3077 9/PG 3
RTECS号 GW4900000

由丁二烯与顺丁烯二酸酐反应后,再与氨,ClSCCl2CHCl2反应,即制得本品。