7327-87-9

• 常用中文名：硫酸双肼屈嗪
• 常用英文名：Dihydralazine sulfate
• CAS号：7327-87-9
• 分子式：C₈H₁₂N₆O₄S
• 分子量：288.284
• 相关类别： 原料药 循环系统用药 抗高血压病药
• 发布时间：2018-07-18 09:31:11
• 更新时间：2024-01-02 17:49:24
• Dihydralazine sulfate 是一种抗高血压剂。

名称

• 中文名: 硫酸双肼屈嗪
• 英文名: (4-hydrazinylphthalazin-1-yl)hydrazine,sulfuric acid
• 中文别名: 1,4-双肼基-2,3-二氮杂萘的硫酸盐二倍半水合物
• 英文别名: EINECS 230-808-0; Depressan; 1,4-dihydrazino-phthalazine,sulfate; MFCD00035271; dihydrazino-1,4-phthalazine sulfate; 1,4-dihydrazinophthalazine sulfate(1:1); Phthalazine,1,4-dihydrazino-,sulfate (1:1); Phthalazine, 1,4-bis(hydrazinyl)-, sulfate (1:1); 1,4-Dihydrazino-phthalazin,Sulfat; 1,4-dihydrazinylphthalazine sulfate (1:1); 1,4-Dihydrazinophthalazine hydrogen sulfate; (1Z,4Z)-1,4-dihydrazinylidene-1,2,3,4-tetrahydrophthalazine sulfate (1:1); Dihydralazine sulphate; Sulfate de dihydralazine [French]; 4-Hydrazino-1-hydrazono-1,2-dihydrophthalazine sulfate (1:1); Dihydralazine sulfate; 1,4-phthalazinedione, 2,3-dihydro-, dihydrazone, (1Z,4Z)-, sulfate (1:1); dihydralazine

物化性质

• 沸点: 648.3ºC
• 分子式: C₈H₁₂N₆O₄S
• 分子量: 288.284
• 闪点: 345.9ºC
• 精确质量: 288.064087
• PSA: 184.86000
• LogP: 2.17560
• 储存条件: 室温，保存在惰性气体中

生物活性

• 描述: Dihydralazine sulfate 是一种抗高血压剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Bijvank SW, et al. Ketanserin versus dihydralazine for the treatment of severe hypertension in early-onset preeclampsia: a double blind randomized controlled trial. Eur J Obstet Gynecol Reprod Biol. 2015 Jun;189:106-11.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TH8880000 CAS REGISTRY NUMBER : 7327-87-9 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C8-H10-N6.H2-O4-S MOLECULAR WEIGHT : 288.32 WISWESSER LINE NOTATION : T66 CNNJ BMZ EMZ &S-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 159 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 223 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : DNA damage MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 79500 ug/kg REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,605,1982

安全

• 危险品运输编码: NONH for all modes of transport