4968-09-6

• 常用中文名：阿孕奈德
• 常用英文名：Alphasone acetonide
• CAS号：4968-09-6
• 分子式：C₂₄H₃₄O₄
• 分子量：386.52400
• 相关类别： 原料药 激素及调节内分泌功能类药 雌激素及孕激素类药
• 发布时间：2018-08-01 10:01:06
• 更新时间：2024-01-04 10:26:15

名称

• 中文名: 阿孕奈德
• 英文名: algestone acetonide
• 英文别名: progesterone 16,17-acetonide; ALGESTONE ACETONIDE; 16a,17a-isopropylidenedioxyprogesterone; 4-PREGNEN-16ALPHA,17ALPHA-DIOL-3,20-DIONE 16,17-ACETONIDE; Alphasone acetonide

物化性质

• 密度: 1.16g/cm3
• 沸点: 501.5ºC at 760 mmHg
• 熔点: 210°
• 分子式: C₂₄H₃₄O₄
• 分子量: 386.52400
• 闪点: 216.1ºC
• 精确质量: 386.24600
• PSA: 52.60000
• LogP: 4.60750
• 折射率: 1.554

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TU5011600 CHEMICAL NAME : Pregn-4-ene-3,20-dione, 16-alpha,17-dihydroxy-, cyclic acetal with acetone CAS REGISTRY NUMBER : 4968-09-6 LAST UPDATED : 199712 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C24-H34-O4 MOLECULAR WEIGHT : 386.58 WISWESSER LINE NOTATION : T F5 E5 B666 GO IO RV PUTJ A1 E1 FV1 H1 H1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin DOSE : 250 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 7,341,1966

合成路线

27336-10-3 ~75% 4968-09-6

文献：Datcheva, Violeta K.; Voishvillo, Natalia E.; Kamernitskii, Aleksei V.; Vlahov, Radoslav J.; Reshetova, Irina G. Steroids, 1989 , vol. 54, # 3 p. 271 - 286

26302-61-4 ~10% 4968-09-6 124800-67-5

文献：Pharmaceutical Chemistry Journal, , vol. 26, # 2 p. 177 - 182 Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 2 p. 64 - 68

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