19982-08-2

• 常用中文名：3,5-二甲基金刚胺
• 常用英文名：memantine
• CAS号：19982-08-2
• 分子式：C₁₂H₂₂ClN
• 分子量：179.302
• 相关类别： 原料药 神经系统用药 抗震颤麻痹药
• 发布时间：2018-06-27 16:34:09
• 更新时间：2024-01-02 14:11:28
• 【用途一】
  是一种新型的抗老年痴呆药，可用于中度到重度老年性痴呆症的治疗

名称

• 中文名: 3,5-二甲基金刚胺
• 英文名: memantine
• 中文别名: 二甲金刚烷胺
• 英文别名: Acid salts MeMantine; memantine; 3,5-Dimethyl-1-adamantylamine; MFCD02114015; 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine; Memantina [INN-Spanish]; 3,5-Dimethyl-1-adamantanamine; 3,5-Dimethyladamantan-1-amine; 1,3-Dimethylaminoadamantane; MEMENTINE HYDROCHHLORIDE; Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-; tricyclo[3.3.1.13,7]decan-1-amine, 3,5-dimethyl-; 3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine; 3,5-Dimethyl-1-aminoadamantane; AURORA KA-7643; 3,5-Dimethyladamantan-1-ylamine; 1,3-dimethyl-5-aminoadamantane; 1-amino-3,5-dimethyl-adamantane

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 239.8±8.0 °C at 760 mmHg
• 熔点: 153ºC
• 分子式: C₁₂H₂₂ClN
• 分子量: 179.302
• 闪点: 92.3±9.7 °C
• 精确质量: 179.167404
• PSA: 26.02000
• LogP: 3.18
• 外观性状: 白色粉末
• 蒸汽压: 0.0±0.5 mmHg at 25°C
• 折射率: 1.554
• 储存条件:

  在密封的贮藏器内，并放置阴凉，干燥的地方保存

• 稳定性:

  常温常压下稳定，避免接触强氧化剂

• 计算化学:

  1、 氢键供体数量：2

  2、 氢键受体数量：1

  3、 可旋转化学键数量：0

  4、 拓扑分子极性表面积（TPSA）：26

  5、 重原子数量： 14

  6、 表面电荷：0

  7、 复杂度：240

  8、 同位素原子数量：0

  9、 确定原子立构中心数量：0

  10、 不确定原子立构中心数量：2

  11、 确定化学键立构中心数量：0

  12、 不确定化学键立构中心数量：0

  13、 共价键单元数量：2

• 更多:

  1.性状：未确定

  2.密度（g/mL,25/4℃）：1.046

  3.相对蒸汽密度（g/mL,空气=1）：未确定

  4.熔点（ºC）：未确定

  5.沸点（ºC,常压）：未确定

  6.沸点（ºC,5.2kPa）：未确定

  7.折射率：未确定

  8.闪点（ºC）：未确定

  9.比旋光度（º）：未确定

  10.自燃点或引燃温度（ºC）：未确定

  11.蒸气压（kPa,25ºC）：未确定

  12.饱和蒸气压（kPa,60ºC）：未确定

  13.燃烧热（KJ/mol）：未确定

  14.临界温度（ºC）：未确定

  15.临界压力（KPa）：未确定

  16.油水（辛醇/水）分配系数的对数值：未确定

  17.爆炸上限（%,V/V）：未确定

  18.爆炸下限（%,V/V）：未确定

  19.溶解性：未确定

MSDS

Name: 1 3-Dimethyl-5-aminoadamantane hydrochloride Material Safety Data Sheet Synonym: 1-Amino-3,5-dimethyladamantane hydrochloride; Memantine hydrochloride; 3,5-Dimethyl-1-adamantanamine hydrochloride; DMAA hydrochloride; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine hydrochloride CAS: 19982-08-2 Section 1 - Chemical Product MSDS Name:1 3-Dimethyl-5-aminoadamantane hydrochloride Material Safety Data Sheet Synonym:1-Amino-3,5-dimethyladamantane hydrochloride; Memantine hydrochloride; 3,5-Dimethyl-1-adamantanamine hydrochloride; DMAA hydrochloride; Tricyclo(3.3.1.1(sup 3,7))decan-1-amine hydrochloride Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 19982-08-2 1,3-Dimethyl-5-aminoadamantane hydroch 99 255-219-6 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: Dust may cause mechanical irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. May cause central nervous system effects and/or neurological effects. Inhalation: May cause respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid breathing dust. Storage: Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 19982-08-2: CAS# 41100-52-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 258 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: N/A Explosion Limits, upper: N/A Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C12H21NHCl Molecular Weight: 215.77 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Dust generation. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 19982-08-2: YD1958750 CAS# 41100-52-1 unlisted. LD50/LC50: Not available. Not available. For CAS 19982-08-2, the free base: TDLo Intramuscular (rat): 14.2 mg/kg anticonvulsant. (RTECS) Carcinogenicity: 1,3-Dimethyl-5-aminoadamantane (the free base) - Not listed by ACGIH, IARC, or NTP. 1,3-Dimethyl-5-aminoadamantane hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 19982-08-2: No information available. CAS# 41100-52-1: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 19982-08-2 is not listed on Canada's Ingredient Disclosure List. CAS# 41100-52-1 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 19982-08-2 is not listed on the TSCA inventory. It is for research and development use only. CAS# 41100-52-1 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 安全声明 (欧洲): S24/25
• 海关编码: 2921300090

合成路线

19982-07-1 ~90% 19982-08-2

文献：SAIRAM ORGANICS PVT. LTD.; PHARMACEUTICAL SOLUTIONS FZCO Patent: WO2009/153806 A2, 2009 ; Location in patent: Page/Page column 7 ;

1204184-74-6 ~42% 19982-08-2

文献：CIPLA LIMITED; PATHI, Srinivas, Laxminarayan; KANKAN, Rajendra, Narayanrao; CURTIS, Philip, Anthony Patent: WO2010/7351 A1, 2010 ; Location in patent: Page/Page column 13 ;

41100-52-1 ~% 19982-08-2

文献：WO2007/117544 A2, ; Page/Page column 38-39 ;

947238-46-2 ~73% 19982-08-2

文献：HEXAL AG Patent: WO2007/96124 A1, 2007 ; Location in patent: Page/Page column 12; 13-14 ;

941-37-7 ~% 19982-08-2

文献：Journal of Medicinal Chemistry, , vol. 6, p. 760 - 763

947238-46-2 17356-08-0 ~% 503-87-7 19982-08-2

文献：EP1908748 A1, ; Page/Page column 8 ;

19982-07-1 ~% 707-37-9 941-37-7 19982-08-2 详细

文献：WO2008/62472 A2, ; Page/Page column 16-17 ;

702-79-4 ~% 19982-08-2

文献：Asian Journal of Chemistry, , vol. 24, # 11 p. 5107 - 5110

351329-88-9 ~% 19982-08-2

文献：WO2010/69555 A1, ; Page/Page column 19-21 ;

上下游产品

上游产品  7
19982-07-1 1204184-74-6 41100-52-1 947238-46-2
941-37-7 702-79-4 351329-88-9
下游产品  1
41100-52-1

海关

海关编码	2921300090
中文概述	2921300090 其他环（烷，烯，萜烯）单胺或多胺（包括其衍生物及它们的盐）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%