390-28-3

• 常用中文名：甲氧明
• 常用英文名：methoxamine
• CAS号：390-28-3
• 分子式：C₁₁H₁₇NO₃
• 分子量：211.25800
• 相关类别： 原料药 循环系统用药 抗休克血管活性药
• 发布时间：2018-08-04 16:42:46
• 更新时间：2024-01-04 19:58:50

名称

• 中文名: 甲氧明
• 英文名: 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol
• 中文别名: ALPHA-(1-氨基乙基)-2,5-二甲氧基苄醇; 甲氧胺
• 英文别名: Methoxaminum; Metoxamina; Vasoxyl; Methoxamedrin; Methoxamedrine; methoxamine hydrochloride; methoxamine; Methoxamin; Metossamina; Pseudomethoxamine; Vasoxine

物化性质

• 沸点: 368.4ºC at 760mmHg
• 分子式: C₁₁H₁₇NO₃
• 分子量: 211.25800
• 闪点: 176.6ºC
• 精确质量: 211.12100
• PSA: 64.71000
• LogP: 1.78470
• 计算化学:

  1.疏水参数计算参考值（XlogP）:0.5

  2.氢键供体数量:2

  3.氢键受体数量:4

  4.可旋转化学键数量:4

  5.互变异构体数量:无

  6.拓扑分子极性表面积:64.7

  7.重原子数量:15

  8.表面电荷:0

  9.复杂度:189

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:2

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DN3870000 CHEMICAL NAME : Benzyl alcohol, alpha-(1-aminoethyl)-2,5-dimethoxy- CAS REGISTRY NUMBER : 390-28-3 LAST UPDATED : 199504 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C11-H17-N-O3 MOLECULAR WEIGHT : 211.29 WISWESSER LINE NOTATION : ZY1&YQR BO1 EO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,105,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 69 mg/kg TOXIC EFFECTS : Cardiac - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 160,22,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 4,105,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4938 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 338 (estimated) No. of Female Employees: 138 (estimated)

安全

• 海关编码: 2922509090

合成路线

103565-48-6 ~% 390-28-3

文献：Osorio-Olivares, Mauricio; Rezende, Marcos Caroli; Sepulveda-Boza, Silvia; Cassels, Bruce K.; Fierro, Angelica Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4055 - 4066

742095-47-2 ~% 390-28-3

文献：Osorio-Olivares, Mauricio; Rezende, Marcos Caroli; Sepulveda-Boza, Silvia; Cassels, Bruce K.; Fierro, Angelica Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4055 - 4066

上下游产品

上游产品  2
103565-48-6 742095-47-2
下游产品  1
30275-30-0

海关

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%