135660-93-4

• 常用中文名：Methyl bromo(2-fluorophenyl)acetate
• 常用英文名：Methyl bromo(2-fluorophenyl)acetate
• CAS号：135660-93-4
• 分子式：C₉H₈BrFO₂
• 分子量：247.061
• 发布时间：2016-04-27 08:50:37
• 更新时间：2024-01-08 09:39:09

名称

• 英文名: Methyl bromo(2-fluorophenyl)acetate
• 英文别名: methyl 5-R,S-benzoyloxy-5-formyl-n-pentanoate; Methyl bromo(2-fluorophenyl)acetate; Benzeneacetic acid, α-bromo-2-fluoro-, methyl ester

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 247.6±25.0 °C at 760 mmHg
• 分子式: C₉H₈BrFO₂
• 分子量: 247.061
• 闪点: 103.5±23.2 °C
• 精确质量: 245.969162
• PSA: 26.30000
• LogP: 2.87
• 蒸汽压: 0.0±0.5 mmHg at 25°C
• 折射率: 1.535

合成路线

57486-67-6 ~99% 135660-93-4

文献：CHIESI FARMACEUTICI S.P.A.; CALIGIURI, Antonio; RICCABONI, Mauro; AMARI, Gabriele Patent: WO2010/72338 A1, 2010 ; Location in patent: Page/Page column 223 ; WO 2010/072338 A1

451-82-1 ~58% 135660-93-4

文献：Pfizer Limited; PFIZER INC. Patent: EP424021 A1, 1991 ;

192884-55-2 ~% 135660-93-4

文献：Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Lain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 900 - 910

389-31-1 ~% 135660-93-4

文献：Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Lain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 900 - 910

446-52-6 ~% 135660-93-4

文献：Astles, Peter C.; Brown, Thomas J.; Halley, Frank; Handscombe, Caroline M.; Harris, Neil V.; Majid, Tahir N.; McCarthy, Clive; McLay, Lain M.; Morley, Andrew; Porter, Barry; Roach, Alan G.; Sargent, Carol; Smith, Christopher; Walsh, Roger J. A. Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 900 - 910