562-09-4

• 常用中文名：Chlorphenoxamine Hydrochloride
• 常用英文名：Chlorphenoxamine Hydrochloride
• CAS号：562-09-4
• 分子式：C₁₈H₂₃Cl₂NO
• 分子量：340.28700
• 发布时间：2017-05-04 13:44:52
• 更新时间：2024-01-02 15:57:08
• Chlorphenoxamine HCl is an antihistaminic agent which reverses multidrug resistance in L1210 tumor cells.

名称

• 英文名: 2-[1-(4-chlorophenyl)-1-phenylethoxy]-N,N-dimethylethanamine,hydrochloride
• 英文别名: Systral; EINECS 209-227-1; Chlorphenoxamine HCl; {2-[1-(4-chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-dimethyl-amine,hydrochloride; chlophenoxamine hydrochloride; Phenoxene; chlorophenoxamine hydrochloride; Contristamine,hydrochloride; 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-N,N-dimethylethanamine hydrochloride; Chlorphenoxamine hydrochloride; Substanz NR. 1766 [German]; {2-[1-(4-Chlor-phenyl)-1-phenyl-aethoxy]-aethyl}-dimethyl-amin,Hydrochlorid; Phenoxene hydrochloride

物化性质

• 沸点: 383.7ºC at 760 mmHg
• 分子式: C₁₈H₂₃Cl₂NO
• 分子量: 340.28700
• 闪点: 185.9ºC
• 精确质量: 339.11600
• PSA: 12.47000
• LogP: 4.98370

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KR2975000 CHEMICAL NAME : Ethylamine, 2-((p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)-N,N -dimethyl-, hydrochloride CAS REGISTRY NUMBER : 562-09-4 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C18-H22-Cl-N-O.Cl-H MOLECULAR WEIGHT : 340.32 WISWESSER LINE NOTATION : GR DX1&R&O2N1&1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,31,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 345 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,262,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 161 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,83,1960 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 159 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,262,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 44 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,262,1954 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 30800 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 4,638,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 220 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,189,1954

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport