34467-12-4

• 常用中文名：3-甲基-5,6-二氢咪唑[2,1-B][1,3]噻唑-2-羧酸盐酸盐
• 常用英文名：ETHYL 3-METHYL-5,6-DIHYDROIMIDAZO[2,1-B][1,3]THIAZOLE-2-CARBOXYLATE HYDROCHLORIDE
• CAS号：34467-12-4
• 分子式：C₉H₁₃ClN₂O₂S
• 分子量：248.73000
• 发布时间：2018-10-12 12:43:44
• 更新时间：2024-04-03 11:32:48

名称

• 中文名: 3-甲基-5,6-二氢咪唑[2,1-B][1,3]噻唑-2-羧酸盐酸盐
• 英文名: ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate,hydrochloride
• 英文别名: 3-methyl-5,6-dihydro-imidazo[2,1-b]thiazole-2-carboxylic acid ethyl ester,hydrochloride; Imidazo(2,1-b)thiazole-2-carboxylic acid,5,6-dihydro-3-methyl-,ethyl ester,hydrochloride; ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate hydrochloride; ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate hydrochloride(1:1)

物化性质

• 沸点: 318.4ºC at 760mmHg
• 熔点: 194-195ºC
• 分子式: C₉H₁₃ClN₂O₂S
• 分子量: 248.73000
• 闪点: 146.3ºC
• 精确质量: 248.03900
• PSA: 71.83000
• LogP: 1.18660

MSDS

Name: Ethyl 3-methyl-5 6-dihydroimidazo[2 1-b][1 3]thiazole-2-carboxylate Material Safety Data Sheet Synonym: CAS: 34467-12-4 Section 1 - Chemical Product MSDS Name:Ethyl 3-methyl-5 6-dihydroimidazo[2 1-b][1 3]thiazole-2-carboxylate Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 34467-12-4 Ethyl 3-methyl-5,6-dihydroimidazo[2,1- 95+% unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 34467-12-4: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 194 - 195 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C9H13ClN2O2S Molecular Weight: 248.73 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, chlorine, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 34467-12-4: NJ5928360 LD50/LC50: Not available. Carcinogenicity: Ethyl 3-methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole-2-carboxylate hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 34467-12-4: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 34467-12-4 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 34467-12-4 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NJ5928360 CHEMICAL NAME : Imidazo(2,1-b)thiazole-2-carboxylic acid, 5,6-dihydro-3-methyl-, ethyl ester, hydrochloride CAS REGISTRY NUMBER : 34467-12-4 LAST UPDATED : 198609 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C9-H12-N2-O2-S.Cl-H MOLECULAR WEIGHT : 248.75 WISWESSER LINE NOTATION : T55 AN DN FS DUT&J GVO2 H1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,604,1981

安全

• 安全声明 (欧洲): S24/25
• 海关编码: 2934100090

合成路线

96-45-7 609-15-4 ~50% 34467-12-4

文献：Powers, Larry J.; Fogt, S. W.; Ariyan, Z. S.; Rippin, D. J.; Heilman, R. D.; Matthews, Richard J. Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 604 - 609

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海关

海关编码	2934100090
中文概述	2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%