616-68-2

• 常用中文名：三甲卡因
• 常用英文名：trimecaine
• CAS号：616-68-2
• 分子式：C₁₅H₂₄N₂O
• 分子量：248.364
• 相关类别： 原料药 Anesthetic Agents Local anesthetics
• 发布时间：2018-04-12 08:00:00
• 更新时间：2024-01-09 18:56:30

名称

• 中文名: 三甲卡因
• 英文名: 2-(diethylamino)-N-(2,4,6-trimethylphenyl)acetamide
• 中文别名: 美索卡因; 2-(二乙基氨基)-N-均三甲苯基乙酰胺; 三甲咔因
• 英文别名: Justecaina; Trimecain; Mesidicain; trimecaine; Acetamide, 2-(diethylamino)-N-(2,4,6-trimethylphenyl)-; Mesokain; N,N-Diethyl-N-mesitylglycinamide; 2-Diethylaminoacetyl-2',4',6'-trimethylanilide; Mesidicaine; N-sym-Trimethylphenyldiethylaminoacetamide; Diethylglycinemesidide; Mesocaine

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 360.3±30.0 °C at 760 mmHg
• 熔点: 44°
• 分子式: C₁₅H₂₄N₂O
• 分子量: 248.364
• 闪点: 171.7±24.6 °C
• 精确质量: 248.188858
• PSA: 32.34000
• LogP: 2.82
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.544

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AE2075000 CHEMICAL NAME : Acetanilide, 2-(diethylamino)-2',4',6'-trimethyl- CAS REGISTRY NUMBER : 616-68-2 BEILSTEIN REFERENCE NO. : 2697351 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C15-H24-N2-O MOLECULAR WEIGHT : 248.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 180 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 23,222,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 295 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 48,402,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 187 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 50,112,1987 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 129 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 39,426,1976

合成路线

603-71-4 ~% 616-68-2

文献：Arkiv foer Kemi, , vol. 22A, # 18 p. 11

88-05-1 ~% 616-68-2

文献：Arkiv foer Kemi, , vol. 22A, # 18 p. 11

3910-51-8 109-89-7 ~% 616-68-2

文献：Arkiv foer Kemi, , vol. 22A, # 18 p. 11

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