123407-36-3

• 常用中文名：阿替夫林
• 常用英文名：ARTEFLENE
• CAS号：123407-36-3
• 分子式：C₁₉H₁₈F₆O₃
• 分子量：408.33500
• 发布时间：2018-02-20 08:00:00
• 更新时间：2024-01-12 00:51:45

名称

• 中文名: 阿替夫林
• 英文名: (1R,2R,5S,6S)-2-[(Z)-2-[2,4-bis(trifluoromethyl)phenyl]ethenyl]-2,6-dimethyl-3,4-dioxabicyclo[3.3.1]nonan-7-one
• 英文别名: Arteflene (USAN/INN); Ro 42-1611; UNII-5PE5HV9NF0; 2,3-Dioxabicyclo(3.3.1)nonan-7-one,4-(2-(2,4-bis(trifluoromethyl)phenyl)ethenyl)-4,8-dimethyl-(1S-(1alpha,4beta(Z),5alpha,8beta)); C19H18F6O3; Arteflene

物化性质

• 密度: 1.348g/cm3
• 沸点: 366.7ºC at 760mmHg
• 分子式: C₁₉H₁₈F₆O₃
• 分子量: 408.33500
• 闪点: 169.6ºC
• 精确质量: 408.11600
• PSA: 35.53000
• LogP: 5.44170
• 蒸汽压: 1.43E-05mmHg at 25°C
• 折射率: 1.507

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : JG6813000 CHEMICAL NAME : 2,3-Dioxabicyclo(3.3.1)nonan-7-one, 4-(2-(2,4-bis(trifluoromethyl)phenyl)ethenyl)-4,8- dimethyl-, (1S-(1-alpha,4-beta(Z),5-alpha,8-beta))- CAS REGISTRY NUMBER : 123407-36-3 LAST UPDATED : 199606 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C19-H18-F6-O3 MOLECULAR WEIGHT : 408.37 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TMPRAD Tropenmedizin und Parasitologie. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.25- 1974- Volume(issue)/page/year: 45,261,1994 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : TMPRAD Tropenmedizin und Parasitologie. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.25- 1974- Volume(issue)/page/year: 45,261,1994 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease REFERENCE : TMPRAD Tropenmedizin und Parasitologie. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.25- 1974- Volume(issue)/page/year: 45,261,1994 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >2500 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : TMPRAD Tropenmedizin und Parasitologie. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.25- 1974- Volume(issue)/page/year: 45,261,1994