143-98-6

• 常用中文名：去甲右美沙芬酒石酸盐
• 常用英文名：Dextrorphan tartrate
• CAS号：143-98-6
• 分子式：C₂₁H₂₉NO₇
• 分子量：407.457
• 相关类别： 分析化学 标准品 标准物质
• 发布时间：2018-08-19 09:20:16
• 更新时间：2024-01-09 18:48:37
• Dextrophan tartrate is a glutamate receptor antagonist potentially for the treatment of stroke. Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextrorotatory-stereoisomer of racemorphan, the levo-half being levorphanol. Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the psychoactive effects of dextromethorphan.

名称

• 中文名: 去甲右美沙芬酒石酸盐
• 英文名: Dextrorphan tartrate
• 英文别名: (2R,3R)-2,3-Dihydroxysuccinic acid - (9α,13α,14α)-17-methylmorphinan-3-ol (1:1); Levorphanol tartrate; 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol tartrate,d; d-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol Tartrate; Dextrorphan Tartrate Salt; 17-Methyl-morphinan-3-ol,Lg-Hydrogentartrat; d-3-Hydroxy-N-methylmorphinan tartrate; Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (9α,13α,14α)-17-methylmorphinan-3-ol (1:1); 17-methyl-morphinan-3-ol,Lg-hydrogentartrate; MFCD00151495; (+)-(9a,13a,14a)-17-methylmorphinan-3-ol Tartrate (1:1) (Salt); Dextrophan tartrate

物化性质

• 沸点: 410.4ºC at 760 mmHg
• 熔点: 201-204°C
• 分子式: C₂₁H₂₉NO₇
• 分子量: 407.457
• 闪点: 207.2ºC
• 精确质量: 407.194397
• PSA: 138.53000
• LogP: 0.89570
• 外观性状: white
• 蒸汽压: 2.55E-07mmHg at 25°C
• 储存条件:

  −70℃

• 水溶解性: H2O: >10mg/mL
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:5

  3.氢键受体数量:8

  4.可旋转化学键数量:3

  5.互变异构体数量:3

  6.拓扑分子极性表面积139

  7.重原子数量:29

  8.表面电荷:0

  9.复杂度:491

  10.同位素原子数量:0

  11.确定原子立构中心数量:5

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD1930000 CAS REGISTRY NUMBER : 143-98-6 LAST UPDATED : 199106 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C17-H23-N-O.C4-H6-O6 MOLECULAR WEIGHT : 407.51 WISWESSER LINE NOTATION : T6 G666/FQ 2AF Q FX ONT&TTJ IQ O &622 QVYQYVQ -D &621 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 385 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 31ZPAG "Synthetic Analgesics," Oxford, Pergamon Press, 1966 Volume(issue)/page/year: 2,77,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17414 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 145,11,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 27500 ug/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953

安全

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P260-P280-P301 + P310-P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): 7-16-36/37-45
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution
• RTECS号: QD1930000