196601-68-0

• 常用中文名：拉科酰胺中间体
• 常用英文名：(R)-benzyl 1-(benzylamino)-3-Methoxy-1-oxopropan-2-ylcarbamate
• CAS号：196601-68-0
• 分子式：C₁₉H₂₂N₂O₄
• 分子量：342.389
• 发布时间：2018-04-25 08:00:00
• 更新时间：2024-01-02 17:38:33

名称

• 中文名: 拉科酰胺中间体
• 英文名: benzyl N-[(1R)-2-(benzylamino)-1-(methoxymethyl)-2-oxo-ethyl]carb amate
• 英文别名: Phenylmethyl [(1R)-1-(methoxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]carbamate; Benzyl [(2R)-1-(benzylamino)-3-methoxy-1-oxo-2-propanyl]carbamate; Carbamic acid, N-[(1R)-1-(methoxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]-, phenylmethyl ester; (R)-(-)-N-BENZYL-1-(1-NAPHTHYL)ETHYLAMI&(R)-N-benzyl-2-(benzyloxycarbonylamino)-3-methoxypropionamide; (R)-N-benzyl 2-N-(benzyloxycarbonyl)amino-3-methoxypropionamide; Carbamic acid, [(1R)-1-(methoxymethyl)-2-oxo-2-[(phenylmethyl)amino]ethyl]-, phenylmethyl ester; (R)-N-BENZYL 1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE; (R)-N-[1-(1-NAPHTHYL)ETHYL]BENZYLAMINE HYDROCHLORIDE; benzyl-(1-naphthalen-1-yl-ethyl)-amine hydrochloride; N-benzyl-1-(1-naphthyl)ethylamine hydrochloride; R1OVMY1O1&VM1R &&R Form; (R)-N-BENZYL 2-(CARBOBENZYLOXYAMINO)-3-METHOXYPROPIONAMIDE

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 586.4±50.0 °C at 760 mmHg
• 分子式: C₁₉H₂₂N₂O₄
• 分子量: 342.389
• 闪点: 308.4±30.1 °C
• 精确质量: 342.157959
• PSA: 83.64000
• LogP: 3.16
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.562
• 储存条件: 室温

合成路线

219835-31-1 74-88-4 ~87% 196601-68-0

文献：LeTiran, Arnaud; Stables, James P.; Kohn, Harold Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4762 - 4773

100-46-9 86096-35-7 543-27-1 ~76% 196601-68-0

文献：Research Corporation Tech., Inc. Patent: US6048899 A1, 2000 ;

77-78-1 219835-31-1 ~77% 196601-68-0

文献：PLIVA HRVATSKA D.O.O. Patent: US2010/240926 A1, 2010 ; Location in patent: Page/Page column 5 ;

6081-61-4 ~% 196601-68-0

文献：King, Amber M.; Salome, Christophe; Dinsmore, Jason; Salome-Grosjean, Elise; De Ryck, Marc; Kaminski, Rafal; Valade, Anne; Kohn, Harold Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4815 - 4830

100-46-9 ~% 196601-68-0

文献：Andurkar, Shridhar V.; Stables, James P.; Kohn, Harold Tetrahedron Asymmetry, 1998 , vol. 9, # 21 p. 3841 - 3854

102988-98-7 ~% 196601-68-0

文献：King, Amber M.; Salome, Christophe; Dinsmore, Jason; Salome-Grosjean, Elise; De Ryck, Marc; Kaminski, Rafal; Valade, Anne; Kohn, Harold Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4815 - 4830

501-53-1 ~% 196601-68-0

文献：MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SRINIVAS, Aluru; SATYANARAYANA, Revu Patent: WO2011/99033 A1, 2011 ;

上下游产品

上游产品  8
219835-31-1 74-88-4 100-46-9 86096-35-7
543-27-1 77-78-1 6081-61-4 501-53-1
下游产品  1
196601-69-1