73-66-5

• 常用中文名：4-Pyrimidinamine,5-(ethoxymethyl)-2-methyl-
• 常用英文名：4-Pyrimidinamine,5-(ethoxymethyl)-2-methyl-
• CAS号：73-66-5
• 分子式：C₈H₁₃N₃O
• 分子量：167.20800
• 相关类别： 化学试剂 有机试剂 脂肪酮(含烯醇)
• 发布时间：2016-01-20 22:38:16
• 更新时间：2024-01-09 07:04:46

名称

• 英文名: 5-(ethoxymethyl)-2-methylpyrimidin-4-amine
• 英文别名: EINECS 200-802-2; 5-Aethoxymethyl-2-methyl-pyrimidin-4-ylamin; 5-Ethoxymethyl-2-methylpyrimidin-4-ylamine; 4-amino-5-ethoxymethyl-2-methylpyrimidine; 4-Amino-2-methyl-5-ethoxymethylpyrimidine; 2-Methyl-4-amino-5-<aethoxymethyl>-pyrimidin; 2-methyl-4-amino-5-ethoxymethylpyrimidine

物化性质

• 密度: 1.113g/cm3
• 沸点: 276.4ºC at 760 mmHg
• 分子式: C₈H₁₃N₃O
• 分子量: 167.20800
• 闪点: 121ºC
• 精确质量: 167.10600
• PSA: 61.03000
• LogP: 1.48490
• 折射率: 1.544

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UV6450000 CHEMICAL NAME : Pyrimidine, 4-amino-5-(ethoxymethyl)-2-methyl- CAS REGISTRY NUMBER : 73-66-5 BEILSTEIN REFERENCE NO. : 0139361 LAST UPDATED : 199612 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C8-H13-N3-O MOLECULAR WEIGHT : 167.24 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1450 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,81,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 239 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,81,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11 mg/m3/17W-I TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,59,1973 ** REPRODUCTIVE DATA ** TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation DOSE : 11 mg/m3 SEX/DURATION : male 17 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR) Volume(issue)/page/year: 13,59,1973 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3 JAN 1993

安全

• 海关编码: 2933599090

合成路线

749835-80-1 ~% 73-66-5

文献：Cline et al. Journal of the American Chemical Society, 1937 , vol. 59, p. 1052

5423-97-2 ~% 73-66-5

文献：Cline et al. Journal of the American Chemical Society, 1937 , vol. 59, p. 1052

109-95-5 874-43-1 ~% 73-66-5

文献：Hoffmann-La Roche Patent: US2480326 , 1946 ;

2141-62-0 ~% 73-66-5

文献：Fodor et al. Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411

3699-10-3 143-37-3 ~% 73-66-5

文献：Fodor et al. Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411

3699-12-5 143-37-3 ~% 73-66-5

文献：Fodor et al. Zhurnal Obshchei Khimii, 1951 , vol. 21, p. 1897,1900; engl. Ausg. S. 2109, 2111 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411

99764-73-5 124-42-5 109-94-4 ~% 73-66-5 详细

文献：Litvak, M. M. Pharmaceutical Chemistry Journal, 1989 , vol. 23, # 11 p. 935 - 938 Khimiko-Farmatsevticheskii Zhurnal, 1989 , vol. 23, # 11 p. 1374 - 1377

64-17-5 3699-10-3 124-42-5 141-52-6 ~% 详细

文献：Takamizawa; Maeda Yakugaku Zasshi, 1954 , vol. 74, p. 746 Chem.Abstr., 1955 , p. 11662 Show Details Takamizawa et al. Yakugaku Zasshi, 1958 , vol. 78, p. 637,642 Chemical and Pharmaceutical Bulletin, 1966 , vol. 14, p. 238 Chem.Abstr., 1958 , p. 18411 Show Details Takamizawa; Hirai Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, p. 393,395

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%