187610-67-9

• 常用中文名：1-(Boc-氨基)-1-羟基甲基环己烷
• 常用英文名：1-(BOC-AMINO)-1-HYDROXYMETHYLCYCLOHEXANE
• CAS号：187610-67-9
• 分子式：C₁₂H₂₃NO₃
• 分子量：229.316
• 发布时间：2018-12-27 23:42:00
• 更新时间：2024-01-05 13:18:07
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名称

• 中文名: 1-(Boc-氨基)-1-羟基甲基环己烷
• 英文名: tert-butyl N-[1-(hydroxymethyl)cyclohexyl]carbamate
• 英文别名: 1-(hydroxymethyl)cyclohexylcarbamic acid tert-butyl ester; tert-butyl 1-(hydroxymethyl)cyclohexylcarbamate; Carbamic acid, N-[1-(hydroxymethyl)cyclohexyl]-, 1,1-dimethylethyl ester; 1-Boc-amino-cyclohexylmethanol; 1-(Boc-amino)-1-hydroxymethylcyclohexane; 1-[1-(tert-butoxycarbonylamino)cyclohexyl]methanol; 2-Methyl-2-propanyl [1-(hydroxymethyl)cyclohexyl]carbamate

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 346.5±11.0 °C at 760 mmHg
• 分子式: C₁₂H₂₃NO₃
• 分子量: 229.316
• 闪点: 163.3±19.3 °C
• 精确质量: 229.167801
• PSA: 62.05000
• LogP: 2.18
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.488

合成路线

115951-16-1 543-27-1 ~65% 187610-67-9

文献：DAIICHI PHARMACEUTICAL CO., LTD. Patent: EP1698626 A1, 2006 ; Location in patent: Page/Page column 142 ;

24424-99-5 2756-85-6 ~66% 187610-67-9

文献：Mutulis, Felikss; Yahorava, Sviatlana; Mutule, Ilze; Yahorau, Aleh; Liepinsh, Edvards; Kopantshuk, Sergei; Veiksina, Santa; Tars, Kaspars; Belyakov, Sergey; Mishnev, Anatoly; Rinken, Ago; Wikberg, Jarl E. S. Journal of Medicinal Chemistry, 2004 , vol. 47, # 18 p. 4613 - 4626

24424-99-5 4313-56-8 ~73% 187610-67-9

文献：Steves, Janelle E.; Stahl, Shannon S. Journal of the American Chemical Society, 2013 , vol. 135, # 42 p. 15742 - 15745

1144505-90-7 ~% 187610-67-9

文献：Shiau, Timothy P.; Houchin, Ashley; Nair, Satheesh; Xu, Ping; Low, Eddy; Najafi, Ramin (Ron); Jain, Rakesh Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1110 - 1114

115951-16-1 ~% 187610-67-9

文献：Chen, Kevin X.; Vibulbhan, Bancha; Yang, Weiying; Nair, Latha G.; Tong, Xiao; Cheng, Kuo-Chi; Njoroge, F. George Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1105 - 1109

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