111-76-2

111-76-2结构式

常用中文名：乙二醇丁醚
常用英文名：2-butoxyethanol
CAS号：111-76-2
分子式：C₆H₁₄O₂
分子量：118.174
相关类别：有机原料醚类化合物及其衍生物醚、醚醇
发布时间：2018-02-05 08:00:00
更新时间：2024-01-02 15:20:03
【用途一】
用作油漆、油墨的溶剂、金属清洗剂组分及染料分散剂的原料
【用途二】
用作测定铁和钼的试剂及溶剂，也用于分离硝酸盐中的钙和锶
【用途三】
主要用作硝酸纤维素、喷漆、快干漆、清漆、搪瓷和脱漆剂的溶剂。还可作纤维润湿剂、农药分散剂、树脂增塑剂、有机合成中间体。测定铁和钼的试剂。改进乳化性能和将矿物油溶解在皂液中的辅助溶剂。
【用途四】
主要用作硝酸纤维素；喷漆；快干漆；清漆；搪瓷和脱漆剂的溶剂。还可作纤维润湿剂；农药分散剂；树脂增塑剂；有机合成中间体。测定铁和钼的试剂。改进乳化性能和将矿物油溶解在皂液中的辅助溶剂。

中文名	乙二醇单丁醚
英文名	2-butoxyethanol
中文别名	丁基溶纤剂乙二醇单丁基醚防白水丁基乙二醇乙二醇单丁 2-丁氧基乙醇乙二醇一丁醚
英文别名	2-Butoxyethanol Ethylene Glycol Mono-Butyl Ether EINECS 203-905-0 Myristic acid,2-hydroxyethyl ester 2-butoxy-ethanol 1-O-Tetradecanoyl-1,2-ethandiol 2-hydroxyethyl butyl ether 2-Butoxy ethanol Ethylene glycol butyl ether 2-n-butyloxyethanol 2-butoxy-1-ethanol 2-hydroxyethyl myristate 2-butoxyethyl alcohol Butyl Glycol Ethyleneglycol-monobutyl ether Tetradecanoic acid,2-hydroxyethyl ester Ethylene glycol monomyristate MFCD00002884 Polyethylene glycol myristate 2-Hydroxyethyl-myristat Ethylene Glycol Monobutyl Ether Butyl Cellosolve Glycol myristate ethylene glycol mono-n-butyl ether

密度	0.9±0.1 g/cm3
沸点	167.7±8.0 °C at 760 mmHg
熔点	-70 °C
分子式	C₆H₁₄O₂
分子量	118.174
闪点	60.0±0.0 °C
精确质量	118.099380
PSA	29.46000
LogP	0.80
外观性状	透明液体
蒸汽密度	4.1 (vs air)
蒸汽压	0.6±0.7 mmHg at 25°C
折射率	1.418
储存条件	1.储存于阴凉、通风的库房。远离火种、热源。包装要求密封，不可与空气接触。 2.应与氧化剂、酸类等分开存放，切忌混储。不宜大量储存或久存。 3.配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性	1.避免与空气接触。禁止与强氧化剂、强酸、酰基氯、酸酐、卤素接触。 2.与本品低毒。对金属无腐蚀性。具有醇的一般化学性质。 3.存在于主流烟气中。 4.小鼠急性经口LD₅₀为1.48g/kg，过量吸入导致溶血、血尿、头痛、呕吐等。
水溶解性	miscible
分子结构	1、摩尔折射率：33.12 2、摩尔体积（cm³/mol）：131.4 3、等张比容（90.2K）：307.2 4、表面张力（dyne/cm）：29.8 5、极化率（10^-24cm³）：13.13
计算化学	1.疏水参数计算参考值（XlogP）:无 2.氢键供体数量:1 3.氢键受体数量:2 4.可旋转化学键数量:5 5.互变异构体数量:无 6.拓扑分子极性表面积29.5 7.重原子数量:8 8.表面电荷:0 9.复杂度:37.5 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:0 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：无色透明液体 2. 沸点（ºC,101.3kPa）：168.4 3. 熔点（ºC）：-74.8 4. 相对密度（g/mL,20/4ºC）：0.9015 5. 相对密度（g/mL,27/4ºC）：0.89460 6. 相对蒸汽密度（g/mL,空气=1）：4.07 7. 折射率_(n²⁰_D) ：1.4187 8. 黏度（mPa·s,25ºC）：3.15 9. 黏度（mPa·s,60ºC）：1.51 10. 闪点（ºC,闭口）：60 11. 闪点（ºC,开口）：74 12. 燃点（ºC）：244 13. 蒸发热（KJ/mol,平均）：48.99 14. 比热容（KJ/(kg·K),25ºC,定压）：2.34 15. 临界温度（ºC）：370 16. 临界压力（MPa）：3.27 17. 电导率（S/m,20ºC）：4.32×10^-7 18. 蒸气压（kPa,94ºC）：6.67 19. 蒸气压（kPa,61ºC）：1.33 20. 蒸气压（kPa,25ºC）：0.11 21. 爆炸下限（%,V/V,170ºC）：1.1 22. 爆炸上限（%,V/V,180ºC）：10.6 23. 体膨胀系数（K^-1,20ºC）：0.00092 24. 溶解性：溶于水、丙酮、苯、乙醚、甲醇、四氯化碳等有机溶剂和矿物油。约46℃时能与水完全混溶。能溶解天然树脂、乙基纤维素、硝化纤维素、醇酸树脂、聚乙二醇、聚醋酸乙烯酯、油脂和石蜡等。 25. 相对密度（25℃，4℃）：0.8457^86.4 26. 临界密度（g·cm^-3）：0.279 27. 临界体积（cm³·mol^-1）：424 28. 临界压缩因子：0.263 29. 偏心因子：0.817 30. 液相标准热熔(J·mol^-1·K^-1) ：285.3

第一部分：化学品名称

化学品中文名称：	乙二醇丁醚
化学品英文名称：	Ethylene glycol monobutyl ether
中文俗名或商品名：
Synonyms：
CAS No.：	111-76-2
分子式：	C₆H₁₄O₂
分子量：	118.17

第二部分：成分/组成信息

纯化学品混合物

化学品名称：乙二醇丁醚

有害物成分

含量

CAS No.

第三部分：危险性概述

危险性类别：	第6．1类毒害品
侵入途径：	吸入食入经皮吸收
健康危害：	吸入本品蒸气后，导致呼吸道刺激及肝肾损害。蒸气对眼有刺激性。皮肤接触可致皮炎。
环境危害：
燃爆危险：	本品可燃，有毒，具刺激性。

第四部分：急救措施

皮肤接触：	脱去污染的衣着，用大量流动清水彻底冲洗。
眼睛接触：	立即提起眼睑，用流动清水冲洗。
吸入：	脱离现场至空气新鲜处。必要时进行人工呼吸。就医。
食入：	误服者给饮大量温水，催吐，就医。

第五部分：消防措施

危险特性：	遇高热、明火或与氧化剂接触，有引起燃烧的危险。接触空气或在光照条件下可生成具有潜在爆炸危险性的过氧化物。若遇高热，容器内压增大，有开裂和爆炸的危险。
有害燃烧产物：	一氧化碳、二氧化碳。
灭火方法及灭火剂：	干粉、泡沫、二氧化碳、砂土。
消防员的个体防护：
禁止使用的灭火剂：
闪点(℃)：	71(O．C)
自燃温度(℃)：	244
爆炸下限[%(V/V)]：	1.1(170℃)
爆炸上限[%(V/V)]：	10.6(180℃)
最小点火能(mJ)：
爆燃点：
爆速：
最大燃爆压力(MPa)：
建规火险分级：

第六部分：泄漏应急处理

应急处理：

疏散泄漏污染区人员至安全区，禁止无关人员进入污染区，切断火源。建议应急处理人员戴好防毒面具，穿化学防护服。在确保安全情况下堵漏。喷水雾会减少蒸发，但不能降低泄漏物在受限制空间内的易燃性。用沙土或其它不燃性吸附剂混合吸收，收集运至废物处理场所处置。也可以用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。

第七部分：操作处置与储存

操作注意事项：

密闭操作，提供充分的局部排风。操作人员必须经过专门培训，严格遵守操作规程。建议操作人员佩戴自吸过滤式防毒面具（半面罩），戴化学安全防护眼镜，穿防毒物渗透工作服，戴橡胶手套。远离火种、热源，工作场所严禁吸烟。使用防爆型的通风系统和设备。防止蒸气泄漏到工作场所空气中。避免与氧化剂、酸类接触。搬运时要轻装轻卸，防止包装及容器损坏。配备相应品种和数量的消防器材及泄漏应急处理设备。倒空的容器可能残留有害物。

储存注意事项：

储存于阴凉、通风的库房。远离火种、热源。包装要求密封，不可与空气接触。应与氧化剂、酸类等分开存放，切忌混储。不宜大量储存或久存。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。

第八部分：接触控制/个体防护

最高容许浓度：	中国MAC：未制定标准苏联MAC：未制定标准美国TWA：ACGIH 25ppm,106mg/m3 TLVWN：未制定标准
监测方法：
工程控制：	严加密闭，提供充分的局部排风。
呼吸系统防护：	可能接触其蒸气时，应该佩带防毒面具。紧急事态抢救或逃生时，佩带自给式呼吸器。
眼睛防护：	高浓度蒸气接触可戴化学安全防护眼镜。
身体防护：	穿相应的防护服。
手防护：	戴防化学品手套。
其他防护：	工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。单独存放被毒物污染的衣服，洗后再用。保持良好的卫生习

第九部分：理化特性

外观与性状：	无色液体，略有气味。
pH：
熔点(℃)：	-74．8
沸点(℃)：	170．2
相对密度(水=1)：	0．90
相对蒸气密度(空气=1)：	4．07
饱和蒸气压(kPa)：	40．00／140℃
燃烧热(kJ/mol)：	无资料
临界温度(℃)：	无资料
临界压力(MPa)：	无资料
辛醇/水分配系数的对数值：
闪点(℃)：	71(O．C)
引燃温度(℃)：	244
爆炸上限%(V/V)：	10.6(180℃)
爆炸下限%(V/V)：	1.1(170℃)
分子式：	C₆H₁₄O₂
分子量：	118.17
蒸发速率：
粘性：
溶解性：	溶于水、乙醇、乙醚等多数有机溶剂。
主要用途：	用作溶剂和测定铁、钼的试剂。

第十部分：稳定性和反应活性

稳定性：	在常温常压下稳定
禁配物：	强氧化剂、强酸、酰基氯、酸酐、卤素。
避免接触的条件：	接触空气。
聚合危害：	不能出现
分解产物：	一氧化碳、二氧化碳。

第十一部分：毒理学资料

急性毒性：	属低毒类 LD50：2500 mg／kg(大鼠经口)；1200 mg/kg(小鼠经口) LC50：无资料
急性中毒：
慢性中毒：
亚急性和慢性毒性：
刺激性：
致敏性：
致突变性：
致畸性：
致癌性：

第十二部分：生态学资料

生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：

第十三部分：废弃处置

废弃物性质：
废弃处置方法：	处置前应参阅国家和地方有关法规。建议用焚烧法处置。
废弃注意事项：

第十四部分：运输信息

危险货物编号：	61592
UN编号：	2369
包装标志：
包装类别：	Ⅲ
包装方法：	小开口钢桶；薄钢板桶或镀锡薄钢板桶（罐）外花格箱；螺纹口玻璃瓶、铁盖压口玻璃瓶、塑料瓶或金属桶（罐）外普通木箱。
运输注意事项：	运输前应先检查包装容器是否完整、密封，运输过程中要确保容器不泄漏、不倒塌、不坠落、不损坏。严禁与酸类、氧化剂、食品及食品添加剂混运。运输时运输车辆应配备相应品种和数量的消防器材及泄漏应急处理设备。运输途中应防曝晒、雨淋，防高温。公路运输时要按规定路线行驶，勿在居民区和人口稠密区停留。
RETCS号：
IMDG规则页码：

第十五部分：法规信息

国内化学品安全管理法规：

化学危险物品安全管理条例 (1987年2月17日国务院发布)，化学危险物品安全管理条例实施细则 (化劳发[1992] 677号)，工作场所安全使用化学品规定 ([1996]劳部发423号)等法规，针对化学危险品的安全使用、生产、储存、运输、装卸等方面均作了相应规定；常用危险化学品的分类及标志 (GB 13690-92)将该物质划为第6.1 类毒害品。

国际化学品安全管理法规：

第十六部分：其他信息

参考文献：	1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间：	年月日
填表部门：
数据审核单位：
修改说明：
其他信息：	1
MSDS修改日期：	年月日

毒理学数据:

1、急性毒性：大鼠经口LD50：2500 mg/kg；小鼠经口LC50：1200mg/kg；兔经皮LD50：0.56mL/kg

2、刺激数据：皮肤- 兔子 500 毫克轻度; 眼- 兔子 100 毫克重度。

3、本品容易被皮肤吸收，工作场所最高容许浓度240mg/m3。毒物的麻醉作用是引起动物死亡的主要原因。尸检见肺充血，严重肾脏充血和血红蛋白尿。滴入动物眼内可引起疼痛、结膜刺激和角膜的轻微暂时性损伤。

生态学数据:

空气中嗅觉阈浓度: 0.35ppmBOD5(五天生化需氧量): 0.71g(氧)/g(样品)(河兰标准)COD(化学需氧量): 2.2g(氧)/g(样品)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KJ8575000

CHEMICAL NAME :: Ethanol, 2-butoxy-

CAS REGISTRY NUMBER :: 111-76-2

BEILSTEIN REFERENCE NO. :: 1732511

LAST UPDATED :: 199712

DATA ITEMS CITED :: 87

MOLECULAR FORMULA :: C6-H14-O2

MOLECULAR WEIGHT :: 118.20

WISWESSER LINE NOTATION :: Q2O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - metabolic acidosis

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 7813 uL/kg

TOXIC EFFECTS :: Behavioral - coma Vascular - BP lowering not characterized in autonomic section Nutritional and Gross Metabolic - metabolic acidosis

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 195 ppm/8H

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 100 ppm

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 470 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 ppm/4H

TOXIC EFFECTS :: Behavioral - ataxia Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 307 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 917 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1230 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Skin and Appendages - hair

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 ppm/7H

TOXIC EFFECTS :: Behavioral - analgesia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 536 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1050 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 220 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 252 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 230 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 139 gm/kg/90D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9324 mg/m3/21D-C

TOXIC EFFECTS :: Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1540 mg/m3/7H/5W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 432 ppm/7H/30D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - hematuria Blood - other changes Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 245 ppm/6H/9D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg/12D-I

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - other changes Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/m3/24H/13W-C

TOXIC EFFECTS :: Endocrine - hypoglycemia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13290 mg/kg/6W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5180 mg/kg/2W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 396 ppm/7H/30D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - hematuria Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 401 ppm/7H/90D-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - hematuria Blood - other changes

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 415 ppm/7H/12W-I

TOXIC EFFECTS :: Blood - microcytosis with or without anemia Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 385 ppm/7H/28D-I

TOXIC EFFECTS :: Blood - other changes Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4500 uL/kg/9D-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 376 ppm/7H/30D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6279 mg/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 200 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 25 ppm/6H

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 12 mg/kg/4H

SEX/DURATION :: female 1-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9440 mg/kg

SEX/DURATION :: female 7-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7 gm/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9440 mg/kg

SEX/DURATION :: female 6-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 200 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 100 ppm/6H

SEX/DURATION :: female 6-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 341,281,1995 *** REVIEWS *** ACGIH TLV-TWA 121 mg/m3 (25 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 50 ppm (240 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,29,1971 OSHA PEL (Gen Indu):8H TWA 50 ppm (240 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 50 ppm (240 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 50 ppm (240 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 50 ppm (240 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL-AUSTRIA:TWA 20 ppm (100 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 25 ppm (121 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (120 mg/m3);STEL 75 ppm (350 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 20 ppm (100 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 20 ppm (100 mg/m3);STEL 40 ppm;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 20 ppm (100 mg/m3);STEL 50 ppm (250 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 20 ppm (100 mg/m3);STEL 40 ppm;Skin JAN 1993 OEL-TURKEY:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ETHYLENE GLYCOL MONOBUTYL ETHER-air:10H TWA 5 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 29930 No. of Facilities: 141929 (estimated) No. of Industries: 398 No. of Occupations: 199 No. of Employees: 1547951 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 29930 No. of Facilities: 130413 (estimated) No. of Industries: 402 No. of Occupations: 239 No. of Employees: 2139297 (estimated) No. of Female Employees: 585932 (estimated)

符号	GHS07
信号词	Warning
危害声明	H302 + H312 + H332-H315-H319
警示性声明	P261-P301 + P312 + P330-P302 + P352 + P312-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	Xn:Harmful
风险声明 (欧洲)	R20/21/22;R36/38
安全声明 (欧洲)	S36/37-S46
危险品运输编码	1986
WGK德国	1
RTECS号	KJ8575000
包装等级	III
危险类别	6.1
海关编码	2909440000

上游产品 10
3390-13-4 107-21-1 123-72-8 112-60-7
111-46-6 112-27-6 75-21-8 71-36-3
139-66-2 10228-54-3
下游产品 10
108063-05-4 109-39-7 109-37-5 50-67-9
141-19-5 18854-51-8 20441-70-7 20442-06-2
20442-11-9 513-35-9

1.由环氧乙烷正丁醇加成而得。将正丁醇在20℃下加入三氟化硼的乙醚溶液中，在搅拌下通入环氧乙烷。随着反应的进行，温度自动上升，待温度下降后，放置三天。用氢氧化钾甲醇溶液中和至pH=8，即得粗品。向粗品中加少许对氨基酚后进行分馏，分集166-170℃馏分，即得成品。工业生产可采用在高温高压（反应温度180-250℃，压力为2.1-4.6MPa）下非催化反应的方法，反应6h。也可采用碱催化剂在近于常压和较低的温度下进行。

精制方法：易含杂质有水、二甘醇一丁醚的聚合物、乙二醇以及微量的酸性物质等。可用分馏或经无水氯化钙、无水硫酸钠干燥后分馏的方法精制。

海关编码	2909499000
中文概述	2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	1099009-18-3
920313-64-0	930439-75-1
1046861-29-3	1018584-77-4