564-36-3

• 常用中文名：麦角考宁
• 常用英文名：Ergocornine
• CAS号：564-36-3
• 分子式：C₃₁H₃₉N₅O₅
• 分子量：561.672
• 发布时间：2018-07-20 14:42:55
• 更新时间：2024-01-02 14:13:56

名称

• 中文名: 麦角考宁
• 英文名: ergocornine
• 中文别名: 麦角碱; 麦角碱,麦角柯宁碱
• 英文别名: Ergotaman, 12'-hydroxy-2',5'-bis(1-methylethyl)-3',6',18-trioxo-, (5'α)-; Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2',5'-bis(1-methylethyl)-, (5'α,10α)-; Ergocornine; (5'α)-12'-hydroxy-3',6',18-trioxo-2',5'-di(propan-2-yl)ergotaman; (5'a)-12'-Hydroxy-2',5'-bis(1-methylethyl)ergotaman-3',6',18-trione; Ergoline-8-carboximidic acid, 9,10-didehydro-6-methyl-N-[(2R,5S,10aS,10bS)-octahydro-10b-hydroxy-2,5-bis(1-methylethyl)-3,6-dioxo-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-, (8β)-; Ergotaman-3',6',18-trione, 12'-hydroxy-2',5'-bis(1-methylethyl)-, (5'α)-; (6aR,9R)-N-[(2R,5S,10aS,10bS)-10b-Hydroxy-2,5-diisopropyl-3,6-dioxooctahydro-8H-[1,3]oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide; (5'; (5'α)-12'-Hydroxy-2',5'-diisopropyl-3',6',18-trioxoergotaman; (8β)-N-[(2R,5S,10aS,10bS)-10b-Hydroxy-2,5-diisopropyl-3,6-dioxooctahydro-8H-[1,3]oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-6-methyl-9,10-didehydroergoline-8-carboximidic acid

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 858.3±65.0 °C at 760 mmHg
• 分子式: C₃₁H₃₉N₅O₅
• 分子量: 561.672
• 闪点: 472.9±34.3 °C
• 精确质量: 561.295105
• PSA: 118.21000
• LogP: 3.55
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.689

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KE7630000 CHEMICAL NAME : Ergotaman-3',6',18-trione, 12'-hydroxy-2',5'-bis(1-methylethyl)-, (5'-alpha)- CAS REGISTRY NUMBER : 564-36-3 BEILSTEIN REFERENCE NO. : 0078784 LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C31-H39-N5-O5 MOLECULAR WEIGHT : 561.75 WISWESSER LINE NOTATION : T C6656 1A P GN LM CUTT&&J G1 EVM- DT B565 CO EVN HVNTJ BQ DY1&1 GY1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 1170 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,304,1948 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 5 mg/kg SEX/DURATION : female 5 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 7,701,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 50 mg/kg SEX/DURATION : female 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 11,459,1966 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 10 mg/kg SEX/DURATION : lactating female 7 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - postpartum REFERENCE : BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 1,367,1969

安全

• 危险品运输编码: UN 1544 6.1/PG 3
• WGK德国: 3
• RTECS号: KE7630000
• 包装等级: III
• 危险类别: 6.1(b)