5985-38-6

• 常用中文名：l-3-hydroxy-n-methylmorphinan dihydrate
• 常用英文名：l-3-hydroxy-n-methylmorphinan dihydrate
• CAS号：5985-38-6
• 分子式：C₂₁H₃₃NO₉
• 分子量：443.48800
• 发布时间：2016-04-08 11:18:26
• 更新时间：2024-01-09 09:32:26
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名称

• 英文名: l-3-hydroxy-n-methylmorphinan dihydrate
• 英文别名: LEVORPHANOL TARTRATE SALT; LEVORPHANOL TARTRATE; levorphanol tartrate dihydrate; LEVORPHANOLTARTRATE,USP; levorphanol tartrate methanol solution; L-3-HYDROXY-N-METHYLMORPHINAN

物化性质

• 沸点: 410.4ºC at 760 mmHg
• 分子式: C₂₁H₃₃NO₉
• 分子量: 443.48800
• 闪点: 11ºC
• 精确质量: 443.21600
• PSA: 156.99000
• LogP: 0.76710

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD1924200 CAS REGISTRY NUMBER : 5985-38-6 LAST UPDATED : 199012 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C17-H23-N-O.C4-H6-O6.2H2-O MOLECULAR WEIGHT : 443.55 WISWESSER LINE NOTATION : T6 G665/FP 2AF P FX ONT&TTJ IQ O1 &QVYQYQVQ &QH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 135 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 45 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951

安全

• 符号: GHS06, GHS08
• 信号词: Danger
• 危害声明: H301-H312 + H332-H317-H334-H360
• 警示性声明: Missing Phrase - N15.00950417-P201-P261-P280-P284-P308 + P313
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): T,F
• 风险声明 (欧洲): R61
• 安全声明 (欧洲): 53-22-36/37-45-16-7
• 危险品运输编码: UN 1544 6.1/PG 3
• RTECS号: QD1924200

合成路线

125-72-4 ~% 5985-38-6

文献：MALLINCKRODT INC. Patent: WO2006/23669 A2, 2006 ; Location in patent: Page/Page column 5-8 ;

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