3335-45-3

3335-45-3结构式

常用中文名：2-羟基-6-(2-噻吩)-4-三氟甲基烟腈
常用英文名：2-hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile
CAS号：3335-45-3
分子式：C₁₁H₅F₃N₂OS
分子量：270.23000
发布时间：2018-06-21 13:54:41
更新时间：2024-01-02 12:11:45

中文名	2-羟基-6-(2-噻吩)-4-三氟甲基烟腈
英文名	2-hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile
英文别名	3-Cyan-6-(2-thienyl)-4-trifluormethyl-2(1H)-pyridon 3-cyano-4-trifluoromethyl-6-(2-thienyl)-2(1H)-pyridone 2-oxo-6-thiophen-2-yl-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile 2-HYDROXY-6-(THIEN-2-YL)-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE 3-cyano-4-difluoromethyl-6-(2-thienyl)-2(1H)-pyridone 2-HYDROXY-6-(2-THIENYL)-4-(TRIFLUOROMETHYL)PYRIDINE-3-CARBONITRILE 4-trifluoromethyl-1,2-dihydro-2-oxo-6-(thiophen-2-yl)pyridine-3-carbonitrile

密度	1.52g/cm3
沸点	390.2ºC at 760mmHg
熔点	278ºC
分子式	C₁₁H₅F₃N₂OS
分子量	270.23000
闪点	189.8ºC
精确质量	270.00700
PSA	85.15000
LogP	3.40618

Name:	2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile 97% Material Safety Data Sheet
Synonym:
CAS:	3335-45-3

Section 1 - Chemical Product MSDS Name:2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile 97% Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
3335-45-3	2-Hydroxy-6-(2-thienyl)-4-(trifluorome	97%	unlisted

Hazard Symbols: XN
Risk Phrases: 20/21/22

Section 3 - HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Harmful by inhalation, in contact with skin and if swallowed.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. Harmful if absorbed through the skin.
Ingestion:
Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation:
Harmful if inhaled. May cause respiratory tract irritation.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 3335-45-3: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 293 - 295 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C11H5F3N2OS
Molecular Weight: 270

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents, acids, bases, oxidizing agents, acid chlorides.
Hazardous Decomposition Products:
Hydrogen cyanide, nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, fluorine, hydrogen fluoride gas.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 3335-45-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION

Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: NITRILES, SOLID, TOXIC, N.O.S.*
Hazard Class: 6.1
UN Number: 3276
Packing Group: III
IMO
Shipping Name: NITRILES, TOXIC, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing Group: III
RID/ADR
Shipping Name: NITRILES, TOXIC, N.O.S.
Hazard Class: 6.1
UN Number: 3276
Packing group: III

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 20/21/22 Harmful by inhalation, in contact with
skin and if swallowed.
Safety Phrases:
S 36/37 Wear suitable protective clothing and
gloves.
WGK (Water Danger/Protection)
CAS# 3335-45-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 3335-45-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 3335-45-3 is not listed on the TSCA inventory.
It is for research and development use only.

SECTION 16 - ADDITIONAL INFORMATION
N/A

危害码 (欧洲)	Xi: Irritant;
风险声明 (欧洲)	36/37/38
安全声明 (欧洲)	26-36/37/39
危险品运输编码	UN 3439
海关编码	2934999090

326-91-0

107-91-5

~97%

3335-45-3

文献：Journal of Sulfur Chemistry, , vol. 32, # 6 p. 611 - 622

326-91-0

2700-22-3

~0%

3335-45-3

81829-55-2

文献：Journal of Organic Chemistry USSR (English Translation), , vol. 18, p. 544 - 548 Zhurnal Organicheskoi Khimii, , vol. 18, # 3 p. 625 - 629

88-15-3

3335-45-3

文献：Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 6 p. 1581 - 1588

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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