60207-90-1

• 常用中文名：丙环唑
• 常用英文名：propiconazole
• CAS号：60207-90-1
• 分子式：C₁₅H₁₇Cl₂N₃O₂
• 分子量：342.220
• 相关类别： 化学农药原药 杀菌剂 其他杀菌剂
• 发布时间：2018-04-27 08:00:00
• 更新时间：2024-01-02 17:52:09
• 丙环唑是一种广谱的三唑类杀菌剂,可抑制羊毛甾醇转化为麦角甾醇,导致真菌细胞膜破裂。丙环唑抑制酿酒酵母,但不抑制大鼠肝脏微粒体细胞色素P450(IC50s分别为0.04µM和>200µM)。丙环唑可抑制变形链球菌和匍匐茎魔芋的生长(ED50s分别为0.073µg/mL和4.6µg/mL)。丙环唑增加活性氧(ROS)的产生。

名称

• 中文名: 丙环唑
• 英文名: propiconazole
• 中文别名: 丙唑灵; 1-[2-(2,4-二氯苯基)-4-丙基-1,3-二氧戊环-2-甲基]-1氢-1,2,4-三唑; 1-[2,4-二氯苯基)-4-丙基-1,3-二氧戊环-2-甲基]-1氢-1,2,4-三唑; 1-[2-(2,4-二氯苯基)-4-丙基-1,3-二氧戊环-α-甲基]-1-氢-1,2,4-三唑; 普克利; 必扑尔; 敌力脱; 氧环三宝25EC; 1-[2-(2,4-二氯苯基)-4-丙基-1,3-二氧戊环-2-基甲基]-1H-1,2,4-三唑
• 英文别名: Bumper; 1-{[2-(2,4-Dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole; 1H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-; 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1H-1,2,4-triazole; propiconazole; FORDO; Juno; MFCD00055299; DESME; Mycostat P; 1-{[(2Ξ,4Ξ)-2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole; 1-[2-(2,4-Dichlorophenyl)-4-propyl-[1,3]dioxolan-2-ylmethyl]-1H-[1,2,4]triazole; proconazole; Orbit; Banner; EINECS 262-104-4; desmel; (2RS,4RS; 2RS,4SR)-1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole; radar; Dadar; Tilt; Wocosin; TRUST; Wocosin 50TK

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 480.0±55.0 °C at 760 mmHg
• 分子式: C₁₅H₁₇Cl₂N₃O₂
• 分子量: 342.220
• 闪点: 244.1±31.5 °C
• 精确质量: 341.069794
• PSA: 49.17000
• LogP: 3.88
• 外观性状: 通常作为黄色液体供应
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.624
• 储存条件:

  4℃

• 稳定性:

  参与丙酮、甲醇、异丙醇等大多数有机溶剂互溶，对光、热、酸、碱都较稳定，对金属无腐蚀性。对兔眼; 睛黏膜和皮肤有轻度刺激，对豚鼠无致敏作用，在试验条件下未见三致现象。

• 水溶解性: 水溶性：不溶；水溶解度：100 mg/l 25 °C；混溶：乙醇,甲苯,丙酮
• 分子结构:

  1、 摩尔折射率：86.41

  2、 摩尔体积（cm³/mol）：244.8

  3、 等张比容（90.2K）：646.1

  4、 表面张力（dyne/cm）：48.4

  5、 极化率（10^-24cm³）：34.25

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积49.2

  7.重原子数量:22

  8.表面电荷:0

  9.复杂度:377

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:2

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：淡黄色黏稠液体

  2. 密度（g/cm³ 20ºC ）：1.27

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC）：180

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率（°）：1.5468

  8. 闪点（ºC）：11

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,20ºC）：0.133×10^-3

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值（25℃）：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性(mg/L 20ºC)：水：110

生物活性

• 描述: 丙环唑是一种广谱的三唑类杀菌剂,可抑制羊毛甾醇转化为麦角甾醇,导致真菌细胞膜破裂。丙环唑抑制酿酒酵母,但不抑制大鼠肝脏微粒体细胞色素P450(IC50s分别为0.04µM和>200µM)。丙环唑可抑制变形链球菌和匍匐茎魔芋的生长(ED50s分别为0.073µg/mL和4.6µg/mL)。丙环唑增加活性氧(ROS)的产生。
• 相关类别:
  信号通路 >> 抗感染 >> 真菌

MSDS

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: Propiconazole CAS-No.: 60207-90-1 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 4) Skin sensitization (Category 1) Acute aquatic toxicity (Category 1) Chronic aquatic toxicity (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC Harmful if swallowed. May cause sensitization by skin contact. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal wordWarning Hazard statement(s) H302Harmful if swallowed. H317May cause an allergic skin reaction. H410Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P273Avoid release to the environment. P280Wear protective gloves. P501Dispose of contents/ container to an approved waste disposal plant. Supplemental Hazardnone Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R22Harmful if swallowed. R43May cause sensitization by skin contact. R50/53Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S-phrase(s) S36/37Wear suitable protective clothing and gloves. S46If swallowed, seek medical advice immediately and show this container or label. S60This material and its container must be disposed of as hazardous waste. S61Avoid release to the environment. Refer to special instructions/ Safety data sheets. Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Formula: C15H17Cl2N3O2 Molecular Weight: 342,22 g/mol ComponentConcentration Propiconazole CAS-No.60207-90-1- EC-No.262-104-4 Index-No.613-205-00-0 Section4. FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: liquid Colour: yellow b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and 180 °C at 0,129 hPa boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityinsoluble o) Partition coefficient: n- log Pow: 3,5 octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity LD50 Oral - rat - 1.517 mg/kg LC50 Inhalation - rat - 4 h - 1.264 mg/m3 LD50 Dermal - rat - > 4.000 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization May cause allergic skin reaction. Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity Reproductive toxicity - rat - Oral Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants). Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation May be fatal if inhaled. May cause respiratory tract irritation. IngestionHarmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. EyesMay cause eye irritation. Additional Information RTECS: XZ4620000 Section12. ECOLOGICAL INFORMATION Toxicity Toxicity to fishLC50 - Oncorhynchus mykiss (rainbow trout) - 0,9 - 1,2 mg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 4,8 mg/l - 48 h other aquatic invertebrates Toxicity to algaeEC50 - Pseudokirchneriella subcapitata (green algae) - 5 mg/l - 72 h Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects Very toxic to aquatic life. Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: 3082IMDG: 3082IATA: 3082 UN proper shipping name ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (Propiconazole) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S. (Propiconazole) IATA:Environmentally hazardous substance, liquid, n.o.s. (Propiconazole) Transport hazard class(es) ADR/RID: 9IMDG: 9IATA: 9 Packaging group ADR/RID: IIIIMDG: IIIIATA: III Environmental hazards ADR/RID: yesIMDG Marine pollutant: yesIATA: yes Special precautions for user Further information EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids. Section15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available Section16. OTHER INFORMATION Further information Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

毒性和生态

毒理学数据: 大鼠急性经口LD50>1517mg/kg，急性经皮LD50> 4000mg/kg,鲤鱼LC50 100 mg /L，虹蝉783mg /L(均96h)。 生态学数据: 对水是稍微危害的，若无政府许可，勿将材料排入周围环境 CHEMICAL IDENTIFICATION RTECS NUMBER : XZ4620000 CHEMICAL NAME : 1H-1,2,4-Triazole, 1-((2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl )methyl)- CAS REGISTRY NUMBER : 60207-90-1 BEILSTEIN REFERENCE NO. : 0841361 LAST UPDATED : 199710 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C15-H17-Cl2-N3-O2 MOLECULAR WEIGHT : 342.25 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1517 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,508,1979 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBCDDQ Proceedings-British Crop Protection Conference-Pests and Diseases. (British Crop., Protection Council, 2A Kidderminster Rd., Croydon, CRO 2UE, UK) 1977- Volume(issue)/page/year: -,508,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 11375 mg/kg/13W-C TOXIC EFFECTS : Liver - hepatitis (hepatocellular necrosis), zonal Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 12,118,1992 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 759 ug/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : BFPHA8 Bulletin of the Faculty of Pharmacy (Cairo University). (Faculty of Pharmacy, Cairo Univ., Cairo, Egypt) V.1- 1961/62- Volume(issue)/page/year: 31,459,1993 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

安全

• 符号: GHS06, GHS09
• 信号词: Danger
• 危害声明: H302-H317-H330-H410
• 警示性声明: P260-P280-P301 + P312 + P330-P304 + P340 + P310-P403 + P233
• 个人防护装备: Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
• 危害码 (欧洲): Xn: Harmful;N: Dangerous for the environment;T: Toxic;F: Flammable;
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): S36/37-S46-S60-S61-S45-S16-S7
• 危险品运输编码: UN3082 9/PG 3
• RTECS号: XZ4620000
• 海关编码: 2934999025

制备

1.先将2，4-二氯苯基甲酮溴化，生成2，4-二氯苯基溴甲基酮。再将2，4-二氯苯基溴甲基酮与1，2-戊二醇在对甲苯磺酸的存在下，于甲苯溶剂中反应生成相应的缩酮。然后在二甲基甲酰胺中与1H-1，2，4-三唑反应，制得丙环唑

制备方法二

制备方法三

海关

海关编码	2934999025
中文概述	2934999025 代森硫,代森环,福吗啉 ,咯菌腈等〔包括稻瘟酯,烯酰吗啉,噻菌腈,土菌灵,恶霜灵,恶霉灵〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途
监管条件	S.进出口农药登记证明
Summary	2934999025 5,6-dihydro-3h-imidazo[2,1-c][1,2,4]dithiazole-3-thione。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%