6533-68-2

• 常用中文名：(-)-东莨菪碱氢溴酸盐
• 常用英文名：Scopolamine hydrobromide trihydrate
• CAS号：6533-68-2
• 分子式：C₁₇H₂₈BrNO₇
• 分子量：438.311
• 相关类别： 化学试剂 有机试剂 酰亚胺
• 发布时间：2018-09-04 17:38:09
• 更新时间：2024-01-02 21:06:50
• 【用途一】
  是一个支气管扩张剂，适用于慢性阻塞性肺疾病（COPD）的维持治疗，包括慢性支气管炎和肺气肿，伴随性呼吸困难的维持治疗及急性发作的预防。

名称

• 中文名: 氢溴酸菪胺
• 英文名: (-)-Scopolamine hydrobromide trihydrate
• 中文别名: 氘代氢溴酸东莨菪碱-d3; 氢溴酸东莨菪碱; 氢溴酸东莨菪胺; 东莨菪碱氢溴酸盐三水合物
• 英文别名: EINECS 204-050-6; Scopolamine hydrobromide; Benzeneacetic acid, α-(hydroxymethyl)-, (1S,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl ester, (αS)-, hydrobromide, hydrate (1:1:3); (1S,2R,4S,5S,7R)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate hydrobromide trihydrate; MFCD00150066; Scopolamine hydrobromide trihydrate; Hyoscine hydrobromide trihydrate

物化性质

• 密度: 1.31 g/cm3
• 沸点: 460.3ºC at 760 mmHg
• 熔点: 197-194 °C
• 分子式: C₁₇H₂₈BrNO₇
• 分子量: 438.311
• 闪点: 232.2ºC
• 精确质量: 437.104919
• PSA: 89.99000
• LogP: 1.62120
• 外观性状: 白色至灰白色粉末
• 折射率: -25.5 ° (C=5, H2O)
• 储存条件: Poison room
• 稳定性: Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic.

MSDS

Name: Scopolamine Hydrobromide Trihydrate 99.0-101.0% (On The Anhydrous Material Safety Data Sheet Synonym: Atroscine Hydrobromide; Hyoscine Hydrobromide CAS: 6533-68-2 Section 1 - Chemical Product MSDS Name:Scopolamine Hydrobromide Trihydrate 99.0-101.0% (On The Anhydrous Material Safety Data Sheet Synonym:Atroscine Hydrobromide; Hyoscine Hydrobromide Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 6533-68-2 Scopolamine Hydrobromide Trihydrate 98% unlisted Hazard Symbols: T+ Risk Phrases: 26/27/28 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Very toxic by inhalation, in contact with skin and if swallowed.Hygroscopic (absorbs moisture from the air).Light sensitive. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. May cause liver and kidney damage. May cause cardiac disturbances. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death. May cause central nervous system depression. Inhalation: May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, tachycardia, dyspnea (labored breathing), and death. May cause liver and kidney damage. May cause cardiac abnormalities. Inhalation at high concentrations may cause CNS depression and asphixiation. Chronic: May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis (bluish skin due to deficient oxygenation of blood), rapid heart rate, unconsciousness and possible death. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood. Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode when heated. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Runoff from fire control or dilution water may cause pollution. Extinguishing Media: Use water spray to cool fire-exposed containers. Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use water spray, fog or regular foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store protected from light. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 6533-68-2: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: colorless or white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 191.00 - 194.00 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: 700 g/l water (20 c) Specific Gravity/Density: Molecular Formula: C17H21NO4.HBr.3H2O Molecular Weight: 438.30 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, light, dust generation, excess heat, strong oxidants, exposure to moist air or water. Incompatibilities with Other Materials: Moisture, acids, bases, oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen bromide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 6533-68-2: YM4730000 LD50/LC50: Not available. Carcinogenicity: Scopolamine Hydrobromide Trihydrate - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: ALKALOID SALTS, SOLID, N.O.S.* Hazard Class: 6.1 UN Number: 1544 Packing Group: II IMO Shipping Name: ALKALOIDS, SOLID, N.O.S. Hazard Class: 6.1 UN Number: 1544 Packing Group: II RID/ADR Shipping Name: ALKALOID SALTS, SOLID, N.O.S. Hazard Class: 6.1 UN Number: 1544 Packing group: II Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T+ Risk Phrases: R 26/27/28 Very toxic by inhalation, in contact with skin and if swallowed. Safety Phrases: S 1 Keep locked up. S 25 Avoid contact with eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 6533-68-2: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 6533-68-2 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 6533-68-2 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YM4730000 CHEMICAL NAME : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, 6-beta,7-beta-epoxy-, (-)-tropate (ester), hydrobromide, trihydrate CAS REGISTRY NUMBER : 6533-68-2 LAST UPDATED : 199712 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C17-H21-N-O4.Br-H.3H2-O MOLECULAR WEIGHT : 438.37 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1413 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4800 mg/kg/16D-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1470 mg/kg/14W-I TOXIC EFFECTS : Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28800 mg/kg/16D-I TOXIC EFFECTS : Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1470 mg/kg/14W-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Nutritional and Gross Metabolic - weight loss or decreased weight gain MUTATION DATA TYPE OF TEST : Micronucleus test TEST SYSTEM : Rodent - hamster Embryo DOSE/DURATION : 3500 mg/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 392,61,1997

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300-H310-H330
• 警示性声明: P260-P264-P280-P284-P301 + P310-P302 + P350
• 个人防护装备: Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
• 危害码 (欧洲): T+: Very toxic;
• 风险声明 (欧洲): R26/27/28
• 安全声明 (欧洲): S45-S25-S1
• 危险品运输编码: UN1544 6.1/PG 3
• RTECS号: YM4550000
• 危险类别: 6.1