59-58-5

• 常用中文名：丙舒硫胺
• 常用英文名：Prosultiamine
• CAS号：59-58-5
• 分子式：C₁₅H₂₄N₄O₂S₂
• 分子量：356.507
• 相关类别： 化学试剂 有机试剂 氰酸酯/异氰酸酯
• 发布时间：2018-04-08 08:00:00
• 更新时间：2024-01-13 13:44:18

名称

• 中文名: 丙舒硫胺
• 英文名: Prosultiamine
• 中文别名: 维生素 B1 丙基硫化物; N-[(4-氨基-2-甲基-5-嘧啶基)甲基]-N-(4-羟基-1-甲基-2-丙基二硫丁-1-烯基)甲酰胺; 丙硫胺嘧啶
• 英文别名: Aneurimec; tiotiamina; Prosultiamine; 2-(2-Methyl-4-aminopyrimidin-5-yl)methylformamido-5-hydroxy-2-penten-3-yl Propyl Disulfide; Alinamine; TPD; Sintotiamina; neurvita; Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[(1E)-4-hydroxy-1-methyl-2-(propyldithio)-1-buten-1-yl]-; Proneurin; nervilon; N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[(2E)-5-hydroxy-3-(propyldisulfanyl)-2-penten-2-yl]formamide; DTPT; EINECS 200-436-3; nevriton; Nuvelbi V.C.A.; alinamin; N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-[(2E)-5-hydroxy-3-(propyldisulfanyl)pent-2-en-2-yl]formamide; aliton; thiamine propyldisulfide; tipidi; nuvelbiv.c.a.; arinamine

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 593.7±50.0 °C at 760 mmHg
• 分子式: C₁₅H₂₄N₄O₂S₂
• 分子量: 356.507
• 闪点: 312.9±30.1 °C
• 精确质量: 356.134064
• PSA: 142.94000
• LogP: 3.41
• 外观性状: 白色结晶或结晶粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.620
• 储存条件: 2-8°C， 干燥
• 分子结构:

  1、 摩尔折射率：99.28

  2、 摩尔体积（cm³/mol）：282.5

  3、 等张比容（90.2K）：786.1

  4、 表面张力（dyne/cm）：59.9

  5、 极化率（10-24cm3）：39.36

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LQ0699000 CHEMICAL NAME : Formamide, N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydro xy-1-methyl-2- (propyldithio)-1-butenyl)- CAS REGISTRY NUMBER : 59-58-5 LAST UPDATED : 199706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C15-H24-N4-O2-S2 MOLECULAR WEIGHT : 356.55 WISWESSER LINE NOTATION : T6N CNJ B1 DZ E1NVHY1&UY2QSS3 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,724,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 650 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,724,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,724,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 37500 mg/kg/15D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : INDRBA Indian Drugs. (Indian Drugs Manufacturers' Assoc., 102B, Poonam Chambers, Dr. A. B. Rd., Worli, Bombay 400 018, India) V.1- 1963- Volume(issue)/page/year: 12,13,1974/1975

安全

• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): 26-36/37/39

合成路线

1948-52-3 67-03-8 ~% 59-58-5

文献：Yakugaku Zasshi, , vol. 73, p. 216,217 Chem.Abstr., , p. 2071 Yakugaku Zasshi, , vol. 73, p. 497,500 Chem.Abstr., , p. 3372 Journal of Vitaminology, , vol. 1, p. 13,20,23,25 Zeitschrift fuer Naturforschung, , vol. 12b, p. 687,695

67-03-8 ~% 59-58-5

文献：Yakugaku Zasshi, , vol. 73, p. 497,500 Chem.Abstr., , p. 3372 Journal of Vitaminology, , vol. 1, p. 13,20,23,25

1113-16-2 67-03-8 ~% 59-58-5

文献：Yakugaku Zasshi, , vol. 74, p. 963,965 Chem.Abstr., , p. 10306

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