51-06-9

• 常用中文名：4-氨基-N-(2-二乙氨基乙基)苯甲酰胺
• 常用英文名：procainamide
• CAS号：51-06-9
• 分子式：C₁₃H₂₁N₃O
• 分子量：235.32500
• 相关类别： 原料药 人工合成抗感染类药 磺胺类药及增效剂
• 发布时间：2018-06-21 06:40:25
• 更新时间：2024-01-03 08:32:52
• 普鲁卡因胺是DNA甲基转移酶1(DNMT1)的特异性和有效抑制剂。普鲁卡因胺是一种1A类抗心律失常药。普鲁卡因酰胺具有研究癌症和心律失常的潜力[1][2]。

名称

• 中文名: 普鲁卡因胺
• 英文名: procainamide
• 中文别名: 4-氨基-N-[2-(二乙基氨基)乙基]苯甲酰胺; 4-氨基-n-(2-二乙基氨基乙基)苯甲酰胺
• 英文别名: 4-Amino-N-(2-diethylaminoethyl)benzamide; 4-amino-N-[2-(diethylamino)ethyl]benzamide

物化性质

• 密度: 1.06
• 沸点: 421.8ºC at 760mmHg
• 熔点: 47°C
• 分子式: C₁₃H₂₁N₃O
• 分子量: 235.32500
• 闪点: 208.9ºC
• 精确质量: 235.16800
• PSA: 58.36000
• LogP: 2.31250
• 折射率: 1.5700 (estimate)
• 储存条件: 2-8°C

生物活性

• 描述: 普鲁卡因胺是DNA甲基转移酶1(DNMT1)的特异性和有效抑制剂。普鲁卡因胺是一种1A类抗心律失常药。普鲁卡因酰胺具有研究癌症和心律失常的潜力[1][2]。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 表观遗传学 >> DNA甲基转移酶
• 靶点:

  DNMT1[1]

• 参考文献:

  [1]. Lee BH, et al. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005;280(49):40749-40756.

  [2]. Pritchard B, et al. Procainamide. [Updated 2021 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : CV2275000 CHEMICAL NAME : Benzamide, p-amino-N-(2-(diethylamino)ethyl)- CAS REGISTRY NUMBER : 51-06-9 BEILSTEIN REFERENCE NO. : 2214285 LAST UPDATED : 199612 DATA ITEMS CITED : 18 MOLECULAR FORMULA : C13-H21-N3-O MOLECULAR WEIGHT : 235.37 WISWESSER LINE NOTATION : ZR DVM2N2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 8579 mg/kg/43W-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - fibrosing alveolitis REFERENCE : AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 76,146,1984 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 29 mg/kg TOXIC EFFECTS : Behavioral - tremor REFERENCE : AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave., New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,340,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 1826 mg/kg/13W-I TOXIC EFFECTS : Cardiac - other changes REFERENCE : AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 83,798,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human DOSE/DURATION : 2280 mg/kg/22W TOXIC EFFECTS : Musculoskeletal - joints REFERENCE : BHJUAV British Heart Journal. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1939- Volume(issue)/page/year: 34,284,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 583 mg/kg/12D-C TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) REFERENCE : AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 109,375,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1950 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 42,3628,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 33,292,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 54(3),32,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 525 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 42,3628,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 178 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,551,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 720 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,551,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 49 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 37,551,1985 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 2210 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 21,253,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,833,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 125 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 32,833,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 12,77,1957 *** REVIEWS *** TOXICOLOGY REVIEW INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1960- Volume(issue)/page/year: 15,7,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4172 No. of Facilities: 66 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 8032 (estimated) No. of Female Employees: 7252 (estimated)

安全

• 危害码 (欧洲): T+
• 危险品运输编码: 2811
• 包装等级: Ⅲ
• 海关编码: 2924299090

合成路线

1664-52-4 ~93% 51-06-9

文献：Kelly, Sean M.; Lipshutz, Bruce H. Organic Letters, 2014 , vol. 16, # 1 p. 98 - 101

614-39-1 ~% 51-06-9

文献：JANSSEN PHARMACEUTICA N.V. Patent: WO2006/74984 A1, 2006 ; Location in patent: Page/Page column 42 ; WO 2006/074984 A1

122-04-3 ~% 51-06-9

文献：Iwaya; Yoshida Shionogi Kenkyusho Nenpo, 1952 , # 2 p. 114 Chem.Abstr., 1957 , p. 10424

100-36-7 ~% 51-06-9

文献：Iwaya; Yoshida Shionogi Kenkyusho Nenpo, 1952 , # 2 p. 114 Chem.Abstr., 1957 , p. 10424

100-36-7 62-23-7 ~% 51-06-9

文献：Kelly, Sean M.; Lipshutz, Bruce H. Organic Letters, 2014 , vol. 16, # 1 p. 98 - 101

100-36-7 94-09-7 ~% 51-06-9

文献：Ghielmetti Farmaco, Edizione Scientifica, 1954 , vol. 9, p. 384

62979-81-1 ~% 51-06-9

文献：Yamazaki et al. Yakugaku Zasshi, 1953 , vol. 73, p. 294,296 Chem.Abstr., 1954 , p. 2003

上下游产品

上游产品  7
1664-52-4 614-39-1 122-04-3 100-36-7
62-23-7 94-09-7 62979-81-1
下游产品  1
106790-96-9

海关

海关编码	2924299090
中文概述	2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%