34195-34-1

• 常用中文名：hydrocodone bitartrate
• 常用英文名：hydrocodone bitartrate
• CAS号：34195-34-1
• 分子式：C₂₂H₂₉NO₁₀
• 分子量：467.46600
• 发布时间：2017-10-26 08:32:04
• 更新时间：2024-01-09 19:26:22

名称

• 英文名: hydrocodone bitartrate
• 英文别名: 4,5-Epoxy-3-methoxy-17-methyl-morphinan-6-on,Hydrogentartrat; CODEINE IMP E; Codeine,10-hydroxy; 4,5-Epoxy-3-methoxy-17-methyl-morphin-7-en-6,10-diol; Hydrocodone bitartrate salt hemi(pentahydrate); 4,5-epoxy-3-methoxy-17-methyl-morphinan-6-one,hydrogentartrate; HYDROCODONE BITARTRATE; 7,8-DIDEHYDRO-4,5A-EPOXY-3-METHOXY-17-METHYLMORPHINAN-6A,10-DIOL

物化性质

• 沸点: 461.4ºC at 760mmHg
• 熔点: 198ºC
• 分子式: C₂₂H₂₉NO₁₀
• 分子量: 467.46600
• 闪点: 232.9ºC
• 精确质量: 467.17900
• PSA: 163.06000

MSDS

Section 1. Chemical Product and Company Identification Hydrocodone bitartrate Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym Chemical Name Chemical Family Hydrocodone bitartrate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards in Risks of explosion of the product in presence of static discharge: Not available. Presence of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do Precautions not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in light-resistant containers. Hydrocodone bitartrate Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid. Crystalline powder.)OdorOdorless. TasteNot available. Molecular Weight394.5 g/mole White. Color Not available. pH (1% soln/water) Boiling PointNot available. 146°C (294.8°F) - 148 C. Melting Point Critical TemperatureNot available. Not available. Specific Gravity Vapor PressureNot applicable. Vapor DensityNot available. Not available. Volatility Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water, methanol. SolubilitySoluble in cold water. Partially soluble in methanol. Insoluble in diethyl ether. Section 10. Stability and Reactivity Data The product is stable. Stability Instability TemperatureNot available. Excess heat, dust generation. light, incompatible materials Conditions of Instability Incompatibility with various Reactive with oxidizing agents, alkalis. substances Non-corrosive in presence of glass. Corrosivity Special Remarks onSensitive to light. ReactivityIncompatible with heavy metal salts Special Remarks onNot available. Corrosivity Will not occur. Polymerization Hydrocodone bitartrate Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsHydrocodone Bitartrate (anhydrous CAS no. 143-71-5): Acute oral toxicity (LD50): 375 mg/kg [Rat]. Chronic Effects on Humans May cause damage to the following organs: central nervous system (CNS). Other Toxic Effects onHazardous in case of ingestion. HumansSlightly hazardous in case of skin contact (irritant), of inhalation. Special Remarks onNot available. Toxicity to Animals Special Remarks onMay cause adverse reproductive effects and birth defects (teratogenic). Chronic Effects on Humans May affect genetic material (mutagenic) Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: Harmful if swallowed. May be habit forming. May cause nausea, vomiting, constipaton or diarrhea, dry mouth, loss of appetite, sweating, flushing of the face, drop in body temperature, cold and clammy skin. May affect respiration (respiratory depression, shortness of breath, trouble breathing), behavior/central nervous system (analgesia, headache, dizziness, confusion, drowsiness, euphoria, restlessness, nervousness, lightheadness, weakness, fainting, convulsions, unconciousness), cardiovascular system (abnormal heartbeat, slow heartbeat, low blood pressure), blood (leukocytosis). May cause blurred vision or double vision or pinpoint pupils, painful or decreased urination. Section 12. Ecological Information EcotoxicityNot available. Not available. BOD5 and COD Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are less toxic than the product itself. Toxicity of the Products of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Not applicable. Special Provisions for Transport DOT (Pictograms) Hydrocodone bitartrate Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has Proposition 65found to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances. Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Not listed on AICS. WHMIS (Canada) CLASS D-2B: Material causing other toxic effects (TOXIC). Other Classifications DSCL (EEC)R22- Harmful if swallowed.S46- If swallowed, seek medical advice immediately and show this container or label. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Hydrocodone bitartrate SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QD2840000 CAS REGISTRY NUMBER : 34195-34-1 LAST UPDATED : 199504 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C18-H21-N-O3.C4-H6-O6 MOLECULAR WEIGHT : 449.50 WISWESSER LINE NOTATION : T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JO1 P1 &OVYQYQVO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,42,1959 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 153 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 123,705,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80428 No. of Facilities: 2327 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 9115 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80428 No. of Facilities: 162 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2238 (estimated) No. of Female Employees: 1177 (estimated)

安全

• 危险品运输编码: NONH for all modes of transport