65854-97-9

• 常用中文名：苯妥英D10
• 常用英文名：Phenytoin-d10
• CAS号：65854-97-9
• 分子式：C₁₅H₂D₁₀N₂O₂
• 分子量：262.33000
• 相关类别： 分析化学 分析试剂 离子色谱试剂
• 发布时间：2018-08-07 19:22:06
• 更新时间：2024-01-12 19:33:34

名称

• 中文名: 苯妥英-D10
• 英文名: 5,5-diphenyl-d10-hydantoin
• 英文别名: 5,5-bis-pentadeuteriophenyl-imidazolidine-2,4-dione

物化性质

• 熔点: 295-297ºC
• 分子式: C₁₅H₂D₁₀N₂O₂
• 分子量: 262.33000
• 闪点: 9℃
• 精确质量: 262.15300
• PSA: 58.20000
• LogP: 2.42720
• 储存条件: Refrigerator

生物活性

描述

MSDS

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: Phenytoin-D10 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Flammable liquids (Category 2) Acute toxicity, Oral (Category 3) Acute toxicity, Inhalation (Category 3) Acute toxicity, Dermal (Category 3) Specific target organ toxicity - single exposure (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC Highly flammable. Toxic by inhalation, in contact with skin and if swallowed. Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal wordDanger Hazard statement(s) H225Highly flammable liquid and vapour. H301 + H311 + H331Toxic if swallowed, in contact with skin or if inhaled H370Causes damage to organs. Precautionary statement(s) P210Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P260Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280Wear protective gloves/ protective clothing. P301 + P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P311Call a POISON CENTER or doctor/ physician. Supplemental Hazardnone Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R11Highly flammable. R23/24/25Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. S-phrase(s) S7Keep container tightly closed. S16Keep away from sources of ignition - No smoking. S36/37Wear suitable protective clothing and gloves. S45In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Mixtures ComponentClassificationConcentration Methanol CAS-No.67-56-1Flam. Liq. 2; Acute Tox. 3;50 - 100 % EC-No.200-659-6STOT SE 1; H225, H301 + Index-No.603-001-00-XH311 + H331, H370 Registration number01-2119433307-44-XXXXF, T, R11 - R23/24/25 - R39/23/24/25 For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 Section4. FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Methyl alcohol may be fatal or cause blindness if swallowed., Cannot be made non-poisonous., Effects due to ingestion may include:, Nausea, Headache, Vomiting, Gastrointestinal disturbance, Dizziness, Weakness, Confusion. Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture no data available Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information Use water spray to cool unopened containers. Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations (see section 13). Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store under inert gas. hygroscopic Recommended storage temperature: -20 °C Specific end use(s) no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: liquid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and 64 - 65 °C at 1,013 hPa boiling range g) Flash point9,7 °C - closed cup h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerUpper explosion limit: 36 %(V) flammability orLower explosion limit: 6 %(V) explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative density0,791 g/cm3 at 20 °C n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Auto-ignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid Heat, flames and sparks. Extremes of temperature and direct sunlight. Incompatible materials Acids, Oxidizing agents, Alkali metals, Strong oxidizing agents, Strong acids, Acid chlorides, Acid anhydrides, Reducing agents, Strong reducing agents, Phosphorus halides Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity no data available Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity no data available Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects InhalationToxic if inhaled. May cause respiratory tract irritation. IngestionToxic if swallowed. SkinToxic if absorbed through skin. May cause skin irritation. Eyes May cause eye irritation. Signs and Symptoms of Exposure Methyl alcohol may be fatal or cause blindness if swallowed., Cannot be made non-poisonous., Effects due to ingestion may include:, Nausea, Headache, Vomiting, Gastrointestinal disturbance, Dizziness, Weakness, Confusion. Additional Information RTECS: Not available Section12. ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: 1230IMDG: 1230IATA: 1230 UN proper shipping name ADR/RID: METHANOL, SOLUTION IMDG: METHANOL, SOLUTION IATA:Methanol, SOLUTION Transport hazard class(es) ADR/RID: 3 (6.1)IMDG: 3 (6.1)IATA: 3 (6.1) Packaging group ADR/RID: IIIMDG: IIIATA: II Environmental hazards ADR/RID: noIMDG Marine Pollutant: noIATA: no Special precautions for user no data available Section15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available Section16. OTHER INFORMATION Text of H-code(s) and R-phrase(s) mentioned in Section 3 Acute Tox.Acute toxicity Flam. Liq.Flammable liquids H225Highly flammable liquid and vapour. H301 + H311 +Toxic if swallowed, in contact with skin or if inhaled H331 H370Causes damage to organs. STOT SESpecific target organ toxicity - single exposure FHighly flammable TToxic R11Highly flammable. R23/24/25Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Further information Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

安全

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P260-P280-P301 + P310-P311
• 危害码 (欧洲): F,T
• 风险声明 (欧洲): 11-23/24/25-39/23/24/25
• 安全声明 (欧洲): 7-16-36/37-45
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution

合成路线

120-89-8 1076-43-3 ~96% 65854-97-9

文献：Klumpp, Douglas A.; Yeung, Ka Yeun; Prakash, G. K. Surya; Olah, George A. Synlett, 1998 , # 8 p. 918 - 920

57-41-0 ~98% 65854-97-9

文献：Modutlwa, Nkaelang; Maegawa, Tomohiro; Monguchi, Yasunari; Sajiki, Hironao Journal of Labelled Compounds and Radiopharmaceuticals, 2010 , vol. 53, # 11-12 p. 686 - 692

22583-75-1 ~% 65854-97-9

文献：Arzneimittel-Forschung/Drug Research, , vol. 40, # 10 p. 1076 - 1078

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