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31879-05-7

31879-05-7结构式

常用中文名：菲诺洛芬
常用英文名：calcium(-1) anion; 2-(3-phenoxyphenyl)propanoate
CAS号：31879-05-7
分子式：C₁₅H₁₄O₃
分子量：522.604
相关类别：原料药解热镇痛药非甾抗炎药
发布时间：2018-02-17 08:00:00
更新时间：2024-01-06 11:26:55

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中文名	菲诺洛芬
英文名	fenoprofen
中文别名	2-(3-苯氧苯基)丙酸苯氧布洛芬
英文别名	2-(3-Phennoxyphenyl)propanoicacid EINECS 250-850-3 Fenopolfen (+-)-m-phenoxyhydrotropicacid dl-2-(3-phenoxyphenyl)propionicacid FENOPROFEN (.+/-.)-m-Phenoxyhydratropic acid MFCD00072027 2-(3-Phenoxyphenyl)propanoic acid a-Methyl-3-phenoxybenzeneaceticacid

密度	1.183 g/cm3
沸点	168-171ºC at 0.11 MM HG
分子式	C₁₅H₁₄O₃
分子量	522.604
闪点	141.7ºC
精确质量	522.137146
PSA	46.53000
LogP	3.66700

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MU6646000

CHEMICAL NAME :: Hydratropic acid, m-phenoxy-, (+-)-

CAS REGISTRY NUMBER :: 31879-05-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H14-O3

MOLECULAR WEIGHT :: 242.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 4286 ug/kg

TOXIC EFFECTS :: Endocrine - evidence of thyroid hyperfunction

REFERENCE :: BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,1560,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 1092 mg/kg/13W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - interstitial nephritis Kidney, Ureter, Bladder - other changes

REFERENCE :: MACPAJ Mayo Clinic Proceedings. (Room 1035, Plummer Bldg., Mayo Clinic, Rochester, MN 55905) V.39- 1964- Volume(issue)/page/year: 55,103,1980

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 9386 mg/kg/1Y-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - interstitial nephritis

REFERENCE :: NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 301,1271,1979

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 52,454,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3985779 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg/4D-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 52,454,1980

海关编码	2918990090

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%