2210-93-7

• 常用中文名：1-苯基哌嗪盐酸盐
• 常用英文名：1-PHENYL PIPERAZINE HYDROCHLORIDE
• CAS号：2210-93-7
• 分子式：C₁₀H₁₅ClN₂
• 分子量：198.69200
• 相关类别： 医药中间体 杂环化合物 哌嗪类化合物
• 发布时间：2018-07-24 18:29:55
• 更新时间：2024-01-04 16:20:14

名称

• 中文名: 1-苯基哌嗪盐酸盐
• 英文名: 1-phenylpiperazine,hydrochloride
• 中文别名: N-苯基哌嗪盐酸盐
• 英文别名: 1-Phenylpiperazinium chloride; 1-Phenylpiperazine hydrochloride; Phenobolin hydrochloride; 1-Phenylpiperazine HCl; Piperazine,1-phenyl-,hydrochloride; 4-phenylpiperazine hydrochloride; MFCD00012758; EINECS 218-646-9; phenylpiperazine,chloride; phenylpiperazine hydrochloride; 1-phenylpiperazine dihydrochloride; 1-phenylpiperazin-1-ium chloride; N-phenyl-piperazine hydrochloride; 1-PHENYL PIPERAZINE HYDROCHLORIDE

物化性质

• 密度: 1.028g/cm3
• 沸点: 245 - 250ºC
• 熔点: 247-250 °C(lit.)
• 分子式: C₁₀H₁₅ClN₂
• 分子量: 198.69200
• 闪点: 138.3ºC
• 精确质量: 198.09200
• PSA: 15.27000
• LogP: 2.29200
• 外观性状: 白色至灰白色结晶粉末
• 蒸汽压: 0.00252mmHg at 25°C
• 储存条件:

  保持容器密封，放入紧密的出藏器内，储存在阴凉，干燥的地方

• 稳定性:

  避免氧化物，水分接触

• 分子结构:

  1、 摩尔折射率：49.80

  2、 摩尔体积（m³/mol）：157.7

  3、 等张比容（90.2K）：388.9

  4、 表面张力（dyne/cm）：36.9

  5、 极化率（10 ^-24cm ³）：19.74

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:2

  3.氢键受体数量:2

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积15.3

  7.重原子数量:13

  8.表面电荷:0

  9.复杂度:124

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

• 更多:

  1. 性状：白色晶体

  2. 密度（g/mL,20ºC）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：247-250

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,6mmHg）：未确定

  7. 折射率（nD20）：未确定

  8. 闪点（ºF）：未确定

  9. 比旋光度（）： 未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,100ºC）：未确定

  12. 饱和蒸气压（kPa,20ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：可溶解的

MSDS

Name: 1-Phenylpiperazine hydrochloride 97% Material Safety Data Sheet Synonym: 1-Phenylpiperazinium chloride; Piperazine, 1-phenyl-, hydrochlorid CAS: 2210-93-7 Section 1 - Chemical Product MSDS Name:1-Phenylpiperazine hydrochloride 97% Material Safety Data Sheet Synonym:1-Phenylpiperazinium chloride; Piperazine, 1-phenyl-, hydrochlorid Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 2210-93-7 1-Phenylpiperazine hydrochloride 97 218-646-9 Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin.Hygroscopic (absorbs moisture from the air). Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. Substance is readily absorbed through the skin. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Causes respiratory tract irritation. Can produce delayed pulmonary edema. Chronic: Effects may be delayed. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Do NOT get water inside containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Use with adequate ventilation. Keep from contact with moist air and steam. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 2210-93-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystals Color: white Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 240 deg C Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility in water: Not available. Specific Gravity/Density: Not available. Molecular Formula: C10H14N2.HCl Molecular Weight: 198.70 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Hygroscopic: absorbs moisture or water from the air. Conditions to Avoid: Incompatible materials, excess heat, strong oxidants, exposure to moist air or water. Incompatibilities with Other Materials: Moisture, strong oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 2210-93-7: TM2640000 LD50/LC50: Not available. Carcinogenicity: 1-Phenylpiperazine hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 2210-93-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 2210-93-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 2210-93-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、急性毒性：小鼠腹腔LD50：140mg/kg 生态学数据: 对水是稍微有害的，不要让未稀释或大量的产品接触地下水，水道或者污水系统，若无政府许可，勿将材料排入周围环境 CHEMICAL IDENTIFICATION RTECS NUMBER : TM2640000 CHEMICAL NAME : Piperazine, 1-phenyl-, hydrochloride CAS REGISTRY NUMBER : 2210-93-7 LAST UPDATED : 199007 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C10-H14-N2.Cl-H MOLECULAR WEIGHT : 198.72 WISWESSER LINE NOTATION : T6M DNTJ DR &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 140 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

安全

• 危害码 (欧洲): T
• 风险声明 (欧洲): R23/24/25;R36/37/38
• 安全声明 (欧洲): S26-S28-S36/37/39-S45
• 危险品运输编码: UN 2811 6.1/PG 3
• WGK德国: 3
• RTECS号: TM2640000
• 包装等级: III
• 危险类别: 6.1
• 海关编码: 2933599090

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海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%