CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TX5075000
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CHEMICAL NAME :
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Propane, 1-chloro-1-nitro-
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CAS REGISTRY NUMBER :
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600-25-9
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BEILSTEIN REFERENCE NO. :
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1748601
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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31
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MOLECULAR FORMULA :
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C3-H6-Cl-N-O2
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MOLECULAR WEIGHT :
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123.55
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WISWESSER LINE NOTATION :
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WNYG2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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50 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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510 mg/kg
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - somnolence (general depressed activity)
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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66 gm/m3/3H
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - somnolence (general depressed activity)
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>5000 mL/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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165 mg/kg
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - somnolence (general depressed activity)
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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50 mg/kg
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TOXIC EFFECTS :
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Vascular - other changes Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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2 gm/m3/6H
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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18 gm/m3/2H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - acute pulmonary edema Blood - hemorrhage
MUTATION DATA
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TYPE OF TEST :
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Mutation in microorganisms
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TEST SYSTEM :
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Bacteria - Salmonella typhimurium
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REFERENCE :
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EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 19(Suppl 21),2,1992 *** REVIEWS *** ACGIH TLV-TWA 10 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 20 ppm (100 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,53,1971 OSHA PEL (Gen Indu):8H TWA 20 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 20 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 20 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 20 ppm (100 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 20 ppm (100 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-FINLAND:TWA 20 ppm (100 mg/m3);STEL 30 ppm (150 mg/m3) JAN 1993 OEL-FRANCE:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-GERMANY:TWA 20 ppm (100 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (1 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 20 ppm (100 mg/m3) JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (10 mg/m3) JAN 1993 OEL-TURKEY:TWA 20 ppm (100 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1-CHLORO-1-NITROPROPANE-air:10H TWA 2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18590 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 721 (estimated)
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