461-78-9

• 常用中文名：对氯苯丁胺
• 常用英文名：chlorоphentermine
• CAS号：461-78-9
• 分子式：C₁₀H₁₄ClN
• 分子量：183.67800
• 相关类别： 原料药 消化系统用药 食欲抑制药及其它减肥药
• 发布时间：2018-06-12 08:08:07
• 更新时间：2024-01-09 09:37:43

名称

• 中文名: 对氯苯丁胺
• 英文名: 1-(4-chlorophenyl)-2-methylpropan-2-amine
• 中文别名: 1-(4-氯苯基)-2-甲基-2-丙胺
• 英文别名: Lucofen SA; Chlorphenterminum [INN-Latin]; Effox; Chlorphenterminum; Clorfentermina [INN-Spanish]; 3-(4-chlorophenyl)-2-methyl-2-propylamin; Clorfentermina; Teramine; chlorophentermine; chlorphentermine; Desopimon; 1,1-dimethyl-2-(4-chlorophenyl)ethylamine

物化性质

• 密度: 1.074g/cm3
• 沸点: 255.8ºC at 760mmHg
• 分子式: C₁₀H₁₄ClN
• 分子量: 183.67800
• 闪点: 127ºC
• 精确质量: 183.08100
• PSA: 26.02000
• LogP: 3.32010
• 蒸汽压: 0.016mmHg at 25°C
• 折射率: 1.537

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : SH1050000 CHEMICAL NAME : Phenethylamine, p-chloro-alpha,alpha-dimethyl- CAS REGISTRY NUMBER : 461-78-9 BEILSTEIN REFERENCE NO. : 1099928 LAST UPDATED : 199709 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C10-H14-Cl-N MOLECULAR WEIGHT : 183.70 WISWESSER LINE NOTATION : ZX1&1&1R DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE/DURATION : 5357 ug/kg TOXIC EFFECTS : Autonomic Nervous System - sympathomimetic Vascular - BP elevation not characterized in autonomic section TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 260 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1800 mg/kg/30D-I TOXIC EFFECTS : Behavioral - food intake (animal) Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 720 mg/kg/6W-I TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1800 mg/kg/15W-I TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1800 mg/kg/6W-I TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3900 mg/kg/13W-I TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance Lungs, Thorax, or Respiration - other changes TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 480 mg/kg SEX/DURATION : female 10-21 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) Reproductive - Specific Developmental Abnormalities - immune and reticuloendothelial system TYPE OF TEST : Unscheduled DNA synthesis MUTATION DATA TEST SYSTEM : Rodent - rat DOSE/DURATION : 300 mg/kg/5D (Continuous) REFERENCE : 40QBA3 "Proceedings of the International Congress on Toxicology, Toxicology as a Predictive Science, 1st, Toronto, 1977," Plaa, G.L., and W.A. Duncan, eds., New York, Academic Press, Inc., 1978 Volume(issue)/page/year: -,459,1978 *** REVIEWS *** TOXICOLOGY REVIEW FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 35,89,1976

安全

• 海关编码: 29222900

合成路线

26094-21-3 ~% 461-78-9

文献：Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; Location in patent: Page/Page column 77 ; US 20120252802 A1

5468-97-3 ~% 461-78-9

文献：Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; US 20120252802 A1

78558-98-2 ~% 461-78-9

文献：Ferrari,G. Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 337 - 342

104-83-6 ~% 461-78-9

文献：Ferrari,G. Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 337 - 342

52449-43-1 ~% 461-78-9

文献：Pathway Therapeutics Inc. Patent: US2012/252802 A1, 2012 ; US 20120252802 A1

上下游产品

上游产品  4
5468-97-3 78558-98-2 104-83-6 52449-43-1
下游产品  3
17743-62-3 89516-34-7 5531-31-7

海关

海关编码	2921499090
中文概述	2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%