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65886-71-7

65886-71-7结构式

常用中文名：法扎拉滨
常用英文名：1b-D-Arabinofuranosyl-5-azacytosine
CAS号：65886-71-7
分子式：C₈H₁₂N₄O₅
分子量：244.205
发布时间：2018-09-22 18:11:19
更新时间：2024-01-13 18:47:40

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中文名	法扎拉滨
英文名	1-.β.-D-Arabinofuranosyl-5-azacytosine
中文别名	4-氨基-1-BETA-D-阿拉伯呋喃糖基-1,3,5-三嗪-2(1H)-酮
英文别名	4-Amino-1-(β-D-arabinofuranosyl)-1,3,5-triazin-2(1H)-one 1b-D-Arabinofuranosyl-5-azacytosine 4-Amino-1b-D-arabinofuranosyl-s-triazin-2(1H)-one Fazarabine 5-azacytosine arabinoside ara-AC 1-β-D-Arabinofuranosyl-5-azacytosine 4-Amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one 1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-arabinofuranosyl- 5-azaaracytidine

密度	2.1±0.1 g/cm3
沸点	534.5±60.0 °C at 760 mmHg
熔点	228-230ºC (decomposes)
分子式	C₈H₁₂N₄O₅
分子量	244.205
闪点	277.0±32.9 °C
精确质量	244.080765
PSA	143.72000
LogP	-1.99
蒸汽压	0.0±3.2 mmHg at 25°C
折射率	1.823

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XZ2854400

CHEMICAL NAME :: s-Triazin-2(1H)-one, 4-amino-1-beta-D-arabinofuranosyl-

CAS REGISTRY NUMBER :: 65886-71-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H12-N4-O5

MOLECULAR WEIGHT :: 244.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1557 ug/kg/72H-C

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - agranulocytosis

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 24,297,1983