3131-27-9

• 常用中文名：3-Pyridinemethanol,5-hydroxy-4-(methoxymethyl)-6-methyl-, hydrochloride (1:1)
• 常用英文名：3-Pyridinemethanol,5-hydroxy-4-(methoxymethyl)-6-methyl-, hydrochloride (1:1)
• CAS号：3131-27-9
• 分子式：C₉H₁₄ClNO₃
• 分子量：219.66500
• 发布时间：2017-08-15 04:09:33
• 更新时间：2024-01-30 19:08:33

名称

• 英文名: 5-(hydroxymethyl)-4-(methoxymethyl)-2-methylpyridin-3-ol,hydrochloride
• 英文别名: 4-Methoxymethylpyridoxol hydrochloride; 2-methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine hydrochloride; 5-hydroxy-4-(methoxymethyl)-6-methyl-3-pyridinemethanol,hydrochloride; 4'-O-methylpyridoxine hydrochloride; 5-Hydroxymethyl-4-methoxymethyl-2-methyl-pyridin-3-ol,Hydrochlorid; 4-Methoxymethyl-5-hydroxy-6-methyl-3-pyridinemethanol hydrochloride; 3-Pyridinemethanol,5-hydroxy-4-(methoxymethyl)-6-methyl-,hydrochloride; 3-Hydroxy-5-hydroxymethyl-4-methoxymethyl-2-methylpyridine hydrochloride; ginkgotoxin hydrochloride; 4-Methoxymethylpyridoxine hydrochloride; 5-hydroxymethyl-4-methoxymethyl-2-methyl-pyridin-3-ol,hydrochloride

物化性质

• 密度: 1.218g/cm3
• 沸点: 404.2ºC at 760 mmHg
• 分子式: C₉H₁₄ClNO₃
• 分子量: 219.66500
• 闪点: 198.3ºC
• 精确质量: 219.06600
• PSA: 62.58000
• LogP: 1.53630
• 折射率: 1.562

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UT5010000 CHEMICAL NAME : 3-Pyridinemethanol, 5-hydroxy-4-(methoxymethyl)-6-methyl-, hydrochloride CAS REGISTRY NUMBER : 3131-27-9 LAST UPDATED : 197906 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C9-H13-N-O3.Cl-H MOLECULAR WEIGHT : 219.69 WISWESSER LINE NOTATION : T6NJ B1 CQ D1O1 E1Q &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2150 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 705 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 420 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 21 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 22 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 8 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Bird - pigeon DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 11,922,1961

安全

• 海关编码: 2933399090

合成路线

124-41-4 58-56-0 ~% 3131-27-9

文献：Harris et al. Journal of the American Chemical Society, 1940 , vol. 62, p. 3198,3202

5429-57-2 ~% 3131-27-9

文献：Merck,E. Patent: DE707266 , 1939 ; DRP/DRBP Org.Chem.

5429-57-2 ~% 10597-41-8 3131-27-9 78313-60-7 详细

文献：Efremenko, A. A.; Balyakina, M. V.; Gunar, V. I. Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 2 p. 120 - 125 Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 2 p. 69 - 74

上下游产品

上游产品  3
124-41-4 58-56-0 5429-57-2
下游产品  1
78313-59-4

海关

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%