446292-07-5

• 常用中文名：2-[(2R)-2-羟基-3-[[4-(3-氧代-4-吗啉基)苯基]氨基]丙基]-1H-异吲哚-1,3(2H)-二酮
• 常用英文名：4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone
• CAS号：446292-07-5
• 分子式：C₂₁H₂₁N₃O₅
• 分子量：395.409
• 发布时间：2018-11-22 15:04:43
• 更新时间：2024-01-09 11:50:22

名称

• 中文名: 2-[(2R)-2-羟基-3-[[4-(3-氧代-4-吗啉)苯基]氨基]丙基]-1H-异吲哚-1,3(2H)-二酮
• 英文名: (R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino)propyl)isoindoline-1,3-dione
• 中文别名: 2-[(2R)-2-羟基-3-[[4-(3-氧代-4-吗啉基)苯基]氨基]丙基]-1H-异吲哚-1,3(2H)-二酮
• 英文别名: 2-[(2R)-2-Hydroxy-3-{[4-(3-oxo-4-morpholinyl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 2-[(2R)-2-hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-; 2-[(2R)-2-Hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione; T56 BVNVJ C1YQ1MR D- AT6NV DOTJ &&R Form; 4-[((2R)-Hydroxy-3-phthalimido)propylamine]phenyl-3-morpholinone

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 734.9±60.0 °C at 760 mmHg
• 分子式: C₂₁H₂₁N₃O₅
• 分子量: 395.409
• 闪点: 398.3±32.9 °C
• 精确质量: 395.148132
• PSA: 99.18000
• LogP: 1.02
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.672
• 储存条件: 室温

合成路线

161596-47-0 438056-69-0 ~93% 446292-07-5

文献：Roehrig, Susanne; Straub, Alexander; Pohlmann, Jens; Lampe, Thomas; Pernerstorfer, Josef; Schlemmer, Karl-Heinz; Reinemer, Peter; Perzborn, Elisabeth Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5900 - 5908

1252018-10-2 1074-82-4 ~93% 446292-07-5

文献：APOTEX PHARMACHEM INC.; BODHURI, Prabhudas; WEERATUNGA, Gamini Patent: WO2012/51692 A1, 2012 ; Location in patent: Page/Page column 42-43 ;

5455-98-1 438056-69-0 ~% 446292-07-5

文献：BAYER HEALTHCARE AG Patent: US2010/160301 A1, 2010 ; US 20100160301 A1

136918-14-4 1252018-10-2 ~% 446292-07-5

文献：SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; ANNA REDDY, ambati; VENKAT REDDY, buthukuri Patent: WO2012/32533 A2, 2012 ; Location in patent: Page/Page column 16 ;

122-98-5 ~% 446292-07-5

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PRASAD, Ashok; PAL, Daya, Ram; SHARMA, Mukul, Hari, Prasad; JAIN, Kuldeep, Natwarlal; PATEL, Naitik, Bharatbhai Patent: WO2013/98833 A2, 2013 ;

446292-04-2 ~% 446292-07-5

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PRASAD, Ashok; PAL, Daya, Ram; SHARMA, Mukul, Hari, Prasad; JAIN, Kuldeep, Natwarlal; PATEL, Naitik, Bharatbhai Patent: WO2013/98833 A2, 2013 ;

29518-11-4 ~% 446292-07-5

文献：CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PRASAD, Ashok; PAL, Daya, Ram; SHARMA, Mukul, Hari, Prasad; JAIN, Kuldeep, Natwarlal; PATEL, Naitik, Bharatbhai Patent: WO2013/98833 A2, 2013 ;

136918-14-4 ~% 446292-07-5

文献：FARMAK, A.S.; URBASEK, Miroslav; HRADIL, Pavel; GREPL, Martin; FIALOVA, Petra; OREMUS, Vladimir; SLEZAR, Petr Patent: WO2012/41263 A2, 2012 ;

438056-69-0 ~% 446292-07-5

文献：APOTEX PHARMACHEM INC.; BODHURI, Prabhudas; WEERATUNGA, Gamini Patent: WO2012/51692 A1, 2012 ;

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