55028-70-1

• 常用中文名：15(R)-15-甲基前列腺素E2
• 常用英文名：Arbaprostil
• CAS号：55028-70-1
• 分子式：C₂₁H₃₄O₅
• 分子量：366.492
• 发布时间：2018-06-24 21:50:08
• 更新时间：2024-01-13 21:44:46
• Arbaprostil is a synthetic prostaglandin E analog that protects gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors. Arbaprostil is a prodrug for the potent PGE2.

名称

• 中文名: 阿伯前列素
• 英文名: 15(R)-15-methyl Prostaglandin E2
• 中文别名: 阿巴前列素
• 英文别名: 15(R)-15-Methylprostaglandin E2; CU-83; ,15r); (E,Z)-(1R,2R,3R)-7-[3-Hydroxy-2-[(3R)-(3-hydroxy-3-methyl-1-octenyl)]-5-oxocyclopentyl]-5-heptenoic Acid; ARBAPROSTIL; (5Z,11a,13E,15R)-11,15-Dihydroxy-15-methyl-9-oxoprosta-5,13-dien-1-oic Acid; 9-OXO-11ALPHA,15R-DIHYDROXY-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID; (15R)-15-Methylprostaglandin E2; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-15-methyl-9-oxo-, (5Z,11α,13E,15R)-; (5Z,11α,13E,15R)-11,15-Dihydroxy-15-methyl-9-oxoprosta-5,13-dien-1-oic acid; (15R)-15-Methyl-PGE2

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 535.5±50.0 °C at 760 mmHg
• 分子式: C₂₁H₃₄O₅
• 分子量: 366.492
• 闪点: 291.7±26.6 °C
• 精确质量: 366.240631
• PSA: 94.83000
• LogP: 2.23
• 蒸汽压: 0.0±3.2 mmHg at 25°C
• 折射率: 1.557
• 储存条件: 库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UK7895000 CHEMICAL NAME : Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-15-methyl-9-oxo-, (5Z,11-alpha,13E,15R)- CAS REGISTRY NUMBER : 55028-70-1 LAST UPDATED : 199806 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C21-H34-O5 MOLECULAR WEIGHT : 366.55 WISWESSER LINE NOTATION : L5VTJ B2U4VQ C1U1XQ5&1 DQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 600 ng/kg SEX/DURATION : female 12 week(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 9,523,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2800 ug/kg SEX/DURATION : female 15-22 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,62A,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 84 mg/kg SEX/DURATION : male 63 day(s) pre-mating female 14 day(s) pre-mating - 7 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16(Suppl 4),S949,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 22 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16(Suppl 4),S957,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1400 ug/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,71A,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 10400 ug/kg SEX/DURATION : female 17 ? after conception - 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 16(Suppl 4),S981,1988 *** REVIEWS *** TOXICOLOGY REVIEW AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 113,130,1972