73681-12-6

• 常用中文名：Indecainid
• 常用英文名：Indecainid
• CAS号：73681-12-6
• 分子式：C₂₀H₂₄N₂O
• 分子量：308.41700
• 相关类别： 研究领域 心血管疾病
• 发布时间：2016-12-17 15:22:38
• 更新时间：2024-01-14 15:58:33
• 盐酸依地卡因是一种有效的口服I类局部麻醉药抗心律失常剂[1]。

名称

• 英文名: 9-[3-(propan-2-ylamino)propyl]fluorene-9-carboxamide,hydrochloride
• 英文别名: Indecainide hydrochloride (USAN); 9-(3-((1-Methylethyl)amino)propyl)-9H-fluorene-9-carboxamide hydrochloride; 9H-Fluorene-9-carboxamide,9-(3-((1-methylethyl)amino)propyl)-,monohydrochloride; Indecainide HCl; Indecainide hydrochloride; Decabid (TN)

物化性质

• 分子式: C₂₀H₂₄N₂O
• 分子量: 308.41700
• 精确质量: 308.18900
• PSA: 56.11000
• LogP: 4.75720

生物活性

• 描述: 盐酸依地卡因是一种有效的口服I类局部麻醉药抗心律失常剂[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体内研究: 盐酸依地卡因(0、3、6或9 mg/kg；IV,每天1个月)导致10只雄性大鼠中有6只在试验期间死亡,10只雌性大鼠中的1只在9 mg/kg时死亡[2]。盐酸依地卡因(0、1.5、3或4.5毫克/千克；静脉注射,每天1个月)导致4只狗中有2只在4.5 mg/千克时死亡；在1.5 mg/kg或3 mg/kg时,没有明显的毒性迹象,也没有血液学、血清化学或组织学变化[2]。
• 参考文献:

  [1]. Steinberg MI, et al. Electrophysiological studies of indecainide hydrochloride, a new antiarrhythmic agent, in canine cardiac tissues. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):614-21.

  [2]. Sandusky GE Jr, et al. Toxicology of indecainide hydrochloride after intravenous administration to rats and dogs. Toxicol Lett. 1985 Aug;26(2-3):107-10.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LL6010000 CHEMICAL NAME : 9H-Fluorene-9-carboxamide, 9-(3-((1-methylethyl)amino)propyl)-, monohydrochloride CAS REGISTRY NUMBER : 73681-12-6 LAST UPDATED : 199406 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C20-H24-N2-O.Cl-H MOLECULAR WEIGHT : 344.92 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 82 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,175,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 26,107,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 96 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - muscle weakness REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,175,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,175,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : >5 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 26,107,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,175,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 270 mg/kg/30D-I TOXIC EFFECTS : Endocrine - changes in pituitary weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 26,107,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1138 mg/kg/13W-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 5,175,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 135 mg/kg/30D-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Related to Chronic Data - death REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 26,107,1985