6452-47-7

• 常用中文名：甲胺基甲酰氯
• 常用英文名：Methylcarbamic chloride
• CAS号：6452-47-7
• 分子式：C₂H₄ClNO
• 分子量：93.512
• 相关类别： 化学农药原药 杀虫剂中间体
• 发布时间：2018-03-01 08:00:00
• 更新时间：2024-01-02 16:41:29
• 【用途一】
  甲氨基甲酰氯可广泛用作氨基甲酸酯类杀虫剂如仲丁威、克百威、异丙威、灭多威、混灭威和速灭威等的中间体。
  【用途二】
  农药氨基甲酸酯杀虫剂和除草剂的中间体。

名称

• 中文名: 甲胺基甲酰氯
• 英文名: Methylaminoformyl Chloride
• 中文别名: 甲氨基甲酰氯
• 英文别名: Carbamic chloride, methyl-; EINECS 229-253-7; N-methylcarbamoyl chloride; Methylcarbamic chloride; Methylaminoformylchloride

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 93ºC (dec.)
• 熔点: 45ºC
• 分子式: C₂H₄ClNO
• 分子量: 93.512
• 精确质量: 92.998138
• PSA: 29.10000
• LogP: 0.28
• 外观性状: 白色晶体
• 折射率: 1.416
• 储存条件: 2-8℃
• 计算化学:

  1.疏水参数计算参考值（XlogP）:0.6

  2.氢键供体数量:1

  3.氢键受体数量:1

  4.可旋转化学键数量:0

  5.互变异构体数量:2

  6.拓扑分子极性表面积:29.1

  7.重原子数量:5

  8.表面电荷:0

  9.复杂度:44.9

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Methylaminoformyl chloride Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Methylaminoformyl chloride CAS number:6452-47-7 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C2H4ClNO Molecular weight:93.5 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 22

合成路线

624-83-9 ~56% 6452-47-7

文献：D'Silva, Themistocles D. J.; Lopes, Anibal; Jones, Russell L.; Singhawangcha, Sureerat; Chan, John K. Journal of Organic Chemistry, 1986 , vol. 51, # 20 p. 3781 - 3788

105-40-8 ~0% 624-83-9 6452-47-7

文献：Mironov, V. F.; Kozyukov, V. P.; Orlov, G. I. J. Gen. Chem. USSR (Engl. Transl.), 1981 , vol. 51, # 8 p. 1814 - 1818,1555 - 1559

22013-97-4 ~% 6452-47-7

文献：Synthesis, , # 10 art. no. Z03508SS, p. 1612 - 1618

75-44-5 74-89-5 ~% 6452-47-7

文献：US2480088 , ;

75-44-5 593-51-1 ~% 6452-47-7

文献：Justus Liebigs Annalen der Chemie, , vol. 244, p. 35

上下游产品

上游产品  6
624-83-9 105-40-8 22013-97-4 75-44-5
74-89-5 593-51-1
下游产品  10
463-79-6 593-51-1 105-40-8 624-83-9
7647-01-0 16813-32-4 173424-77-6 652154-14-8
5461-30-3 4089-04-7

制备

【方法一】
甲氨基甲酰氯是由甲胺与光气反应制得。反应方程式：CH₃NH₂+COCl₂→CH₃NHCOCl
将40%的甲胺水溶液汽化，经干燥后与光气以1∶1.3的配比(体积)，甲胺以4m³/h，光气以8.6m³/h(含量60％～70%)的速度分别进入预热器预热，甲胺预热温度控制在220～260℃，光气控制在220～240℃。预热的两种气体进入文氏管，在280～300℃合成，得气体甲氨基甲酰氯。然后用四氯化碳(或氯苯溶液)在0～20℃循环吸收，得10％左右的甲氨基甲酰氯四氯化碳(或氯苯)溶液，或者经35～40℃以下冷却成液态成品。
【方法二】
由甲胺与光气反应制得。将40%的甲胺水溶液汽化，经干燥后与光气以1：1.3的配比（体积），甲胺以4m3/h，光气以8.6m3/h（含量60%-70%）的速度分别进入预热器预热，甲胺预热温度控制在220-260℃，光气控制在200-240℃。预热的两种气体进入试管，在280-300℃合成，得气体甲氨甲酰氯。然后四氯化碳（或氯苯溶液）在0-20℃循环吸收，得10%左右的甲氨甲酰氯（或氯苯）溶液，或者经35-40℃以下冷却成液态成品。