7142-09-8

• 常用中文名：6-氯-2-甲基喹唑啉-4-酮
• 常用英文名：6-Chloro-2-methylquinazolin-4(3H)-one
• CAS号：7142-09-8
• 分子式：C₉H₇ClN₂O
• 分子量：194.618
• 发布时间：2018-10-15 07:11:23
• 更新时间：2024-01-11 22:25:06

名称

• 中文名: 6-氯-2-甲基-4-羟基喹唑啉
• 英文名: 6-Chloro-2-methylquinazolin-4(3H)-one
• 中文别名: 6-氯-2-甲基喹唑啉-4-酮; 6-氯-2-甲基喹唑啉-4-醇; 6-氯-2-甲基-4(1H)-喹唑啉; 6-氯-2-甲基喹唑啉-4(3H)-酮
• 英文别名: 6-chloro-2-methyl-1H-quinazolin-4-one; 6-chloro-2-methylquinazolin-4-ol; 6-Chloro-2-methyl-4(1H)-quinazolinone; 4(1H)-Quinazolinone, 6-chloro-2-methyl-; 4(3H)-quinazolinone, 6-chloro-2-methyl-; 6-Chloro-2-methylquinazolin-4(1H)-one; 6-Chloro-2-methylquinazolin-4(3H)-one

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 355.1±44.0 °C at 760 mmHg
• 分子式: C₉H₇ClN₂O
• 分子量: 194.618
• 闪点: 168.6±28.4 °C
• 精确质量: 194.024689
• PSA: 45.75000
• LogP: 1.31
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.664
• 储存条件: 2-8°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA2600000 CHEMICAL NAME : 4(3H)-Quinazolinone, 6-chloro-2-methyl- CAS REGISTRY NUMBER : 7142-09-8 LAST UPDATED : 198509 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C9-H7-Cl-N2-O MOLECULAR WEIGHT : 194.63 WISWESSER LINE NOTATION : T66 BVM ENJ D1 IG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 751 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 514 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962

安全

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

合成路线

21739-93-5 124-42-5 ~82% 7142-09-8

文献：Liu, Xiaowei; Fu, Hua; Jiang, Yuyang; Zhao, Yufen Angewandte Chemie - International Edition, 2009 , vol. 48, # 2 p. 348 - 351

27007-53-0 124-42-5 ~85% 7142-09-8

文献：Huang, Cheng; Fu, Yuan; Fu, Hua; Jiang, Yuyang; Zhao, Yufen Chemical Communications, 2008 , # 47 p. 6333 - 6335

7033-50-3 ~90% 7142-09-8

文献：Santagati, Natale Alfredo; Bousquet, Ennio; Spadaro, Angelo; Ronsisvalle, Giuseppe Farmaco, 1999 , vol. 54, # 11-12 p. 780 - 784

108-24-7 635-21-2 ~81% 7142-09-8

文献：Okano, Masahiko; Mito, Jun; Maruyama, Yasufumi; Masuda, Hirofumi; Niwa, Tomoko; Nakagawa, Shin-ichiro; Nakamura, Yoshitaka; Matsuura, Akira Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 119 - 132

13421-00-6 124-42-5 ~84% 7142-09-8

文献：Zhang, Xiaodong; Ye, Deju; Sun, Haifeng; Guo, Diliang; Wang, Jiang; Huang, He; Zhang, Xu; Jiang, Hualiang; Liu, Hong Green Chemistry, 2009 , vol. 11, # 11 p. 1881 - 1888

7033-53-6 ~% 7142-09-8 5202-87-9

文献：Journal of the American Chemical Society, , vol. 70, p. 2423

5202-87-9 ~% 7142-09-8

文献：Farmaco, , vol. 54, # 11-12 p. 780 - 784

635-21-2 ~% 7142-09-8

文献：Journal of Medicinal Chemistry, , vol. 33, # 6 p. 1721 - 1728

上下游产品

上游产品  9
21739-93-5 124-42-5 27007-53-0 7033-50-3
108-24-7 635-21-2 13421-00-6 7033-53-6
5202-87-9
下游产品  0

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%