303-53-7

• 常用中文名：环苯扎林
• 常用英文名：cyclobenzaprine
• CAS号：303-53-7
• 分子式：C₂₀H₂₁N
• 分子量：275.38700
• 相关类别： 原料药 Anesthetic Agents 骨骼肌松弛药
• 发布时间：2018-08-12 21:24:31
• 更新时间：2024-01-02 17:55:32

名称

• 中文名: 环苯扎林
• 英文名: cyclobenzaprine
• 英文别名: Cyclobenz; Yurelax; Flexeril; Proeptatriene; Cyclobenzaprinum; 3-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine; Proheptatrien; Proheptatriene; Ciclobenzaprina; Lisseril

物化性质

• 密度: 1.096 g/cm3
• 沸点: 405.9ºC at 760 mmHg
• 分子式: C₂₀H₂₁N
• 分子量: 275.38700
• 闪点: 177.8ºC
• 精确质量: 275.16700
• PSA: 3.24000
• LogP: 4.55380
• 外观性状: 固体
• 折射率: 1.7500 (estimate)

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HP0550000 CHEMICAL NAME : 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, N,N-dimethyl- CAS REGISTRY NUMBER : 303-53-7 LAST UPDATED : 199803 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C20-H21-N MOLECULAR WEIGHT : 275.42 WISWESSER LINE NOTATION : L C676 BY&T&J BU3N1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,338,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 36 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,519,1970

安全

• 海关编码: 2921499090

合成路线

6682-26-4 ~93% 303-53-7

文献：Gowda, Narendra B.; Rao, Gopal Krishna; Ramakrishna, Ramesha A. Tetrahedron Letters, 2010 , vol. 51, # 43 p. 5690 - 5693

18029-54-4 ~% 303-53-7

文献：Journal of Organic Chemistry, , vol. 27, p. 230 - 240

109-54-6 ~% 303-53-7

文献：Journal of Organic Chemistry, , vol. 27, p. 230 - 240

2222-33-5 ~% 303-53-7

文献：Journal of Organic Chemistry, , vol. 27, p. 230 - 240

109-54-6 2222-33-5 ~% 303-53-7

文献：Acta Chemica Scandinavica (1947-1973), , vol. 17, p. 2437 - 2443

上下游产品

上游产品  4
6682-26-4 18029-54-4 109-54-6 2222-33-5
下游产品  1
6682-26-4

海关

海关编码	2921499090
中文概述	2921499090 其他芳香单胺及衍生物及它们的盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%