26117-28-2

• 常用中文名：(S)-2-乙酰氨基-3-巯基丙酸
• 常用英文名：N-Acetyl-D-cysteine
• CAS号：26117-28-2
• 分子式：C₅H₉NO₃S
• 分子量：163.195
• 相关类别： 研究领域 其他
• 发布时间：2018-07-07 23:27:34
• 更新时间：2024-01-10 09:35:00
• N-Acetyl-D-cysteine 具有抗氧化活性,通过与巯基反应清除 ROS,但不能进入谷胱甘肽代谢途径。

名称

• 中文名: N-乙酰基-D-半胱氨酸
• 英文名: (2S)-2-acetamido-3-sulfanylpropanoic acid
• 英文别名: acetylcysteine; Lopac-A-7250; D-Cysteine, N-acetyl-; N-Acetylcysteine; N-acetyl-3-mercaptoalanine; (2S)-2-acetylamino-3-sulfanylpropanoic acid; N-Acetyl-D-cysteine; D-Cysteine,N-acetyl

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 407.7±40.0 °C at 760 mmHg
• 分子式: C₅H₉NO₃S
• 分子量: 163.195
• 闪点: 200.4±27.3 °C
• 精确质量: 163.030319
• PSA: 108.69000
• LogP: -0.15
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.519
• 储存条件: 室温，密闭，干燥

生物活性

• 描述: N-Acetyl-D-cysteine 具有抗氧化活性,通过与巯基反应清除 ROS,但不能进入谷胱甘肽代谢途径。
• 相关类别:
  研究领域 >> 其他
• 体外研究: N-乙酰-D-半胱氨酸(20 mM；1小时预处理；12小时)不会增加细胞内GSH水平,但GSH单酯会增加。D-NAC不能促进缺氧性细胞凋亡。这表明GSH而不是D-NAC或NAC是促进缺氧性细胞凋亡的重要因素[3]。
• 参考文献:

  [1]. Maika Deffieu, et al. Glutathione Participates in the Regulation of Mitophagy in Yeast.J Biol Chem. 2009 May 29;284(22):14828-37.

  [2]. B K Wong,et al. Selective Effects of N-acetylcysteine Stereoisomers on Hepatic Glutathione and Plasma Sulfate in Mice. Toxicol Appl Pharmacol

  [3]. Suparna Qanungo, et al. N-Acetyl-L-cysteine Enhances Apoptosis Through Inhibition of Nuclear factor-kappaB in Hypoxic Murine Embryonic Fibroblasts. J Biol Chem

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: N-Acetyl-D-cysteine Synonyms:(2S)-2-Acetamido-3-sulfanylpropanoic acid Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:N-Acetyl-D-cysteine CAS number:26117-28-2 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C5H9NO3S Molecular weight:163.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 海关编码: 2930909090

海关

海关编码	2930909090
中文概述	2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%