38380-07-3

• 常用中文名：六氯联苯
• 常用英文名：2,2',3,3',4,4'-Hexachlorobiphenyl
• CAS号：38380-07-3
• 分子式：C₁₂H₄Cl₆
• 分子量：360.87800
• 相关类别： 分析化学 食品安全 二噁英，多氯联苯，呋喃
• 发布时间：2018-11-28 08:41:53
• 更新时间：2024-01-11 18:33:56

名称

• 中文名: 2,2',3,3',4,4'-六氯联苯
• 英文名: 2,2',3,3',4,4'-Hexachlorobiphenyl
• 中文别名: 六氯联苯
• 英文别名: 1,2,3-trichloro-4-(2,3,4-trichlorophenyl)benzene

物化性质

• 密度: 1.593 g/cm3
• 沸点: 403.8ºC at 760 mmHg
• 熔点: 151°C
• 分子式: C₁₂H₄Cl₆
• 分子量: 360.87800
• 闪点: 198.9ºC
• 精确质量: 357.84400
• LogP: 7.27400
• 折射率: 1.6270 (rough estimate)
• 储存条件: room temp
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:0

  3.氢键受体数量:0

  4.可旋转化学键数量:1

  5.互变异构体数量:无

  6.拓扑分子极性表面积:0

  7.重原子数量:18

  8.表面电荷:0

  9.复杂度:258

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DV5357000 CHEMICAL NAME : 1,1'-Biphenyl, 2,2',3,3',4,4'-hexachloro- CAS REGISTRY NUMBER : 38380-07-3 LAST UPDATED : 199801 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C12-H4-Cl6 MOLECULAR WEIGHT : 360.86 WISWESSER LINE NOTATION : GR BG CG DR BG CG DG HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 383 mg/kg/13W-C TOXIC EFFECTS : Liver - other changes Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 51,265,1997 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 1470 mg/kg/21D-C TOXIC EFFECTS : Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - cytochrome oxidases (including oxidative phosphorylation) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 36,81,1976 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 320 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,54A,1980 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1280 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 21,54A,1980

安全

• 危害码 (欧洲): N
• 风险声明 (欧洲): 33-50/53
• 安全声明 (欧洲): 60-61

合成路线

87-61-6 ~% 35065-30-6 38380-07-3 52663-78-2 详细

文献：Liu, Peng-Yan; Zheng, Ming-Hui; Zhang, Bing; Xu, Xiao-Bai Chemosphere, 2001 , vol. 43, # 4-7 p. 783 - 785

62720-28-9 ~% 38380-07-3

文献：Bolgar; et al. Chemosphere, 1995 , vol. 31, # 2 p. 2687 - 2705