55896-93-0

• 常用中文名：2-(氯磺酰基)乙酸乙酯
• 常用英文名：Ethyl (chlorosulfonyl)acetate
• CAS号：55896-93-0
• 分子式：C₄H₇ClO₄S
• 分子量：186.614
• 相关类别： 原料药 人工合成抗感染类药 消毒防腐药
• 发布时间：2018-04-23 08:00:00
• 更新时间：2024-01-04 18:18:09
• 下载msds

名称

• 中文名: (氯磺酰基)乙酸乙酯
• 英文名: ethyl 2-chlorosulfonylacetate
• 中文别名: 磺酰氯乙酸乙酯; 2-氯磺酰基乙酸乙酯
• 英文别名: Chlorosulfonyl acetic acid ethyl ester; Ethyl (chlorosulfonyl)acetate; Ethyl2-(Chlorosulfonyl)acetate; ethyl 2-chloranylsulfonylethanoate; Acetic acid, 2-(chlorosulfonyl)-, ethyl ester; ClSO2CH2COOEt; MFCD00036152; ClSO2CH2CO2Et; ethoxycarbonylmethylsulfonyl chloride; ethoxy carbonyl methanesulfonyl chloride; Chlorosulfonyl-acetic acid ethyl ester; EINECS 200-580-7

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 244.3±23.0 °C at 760 mmHg
• 熔点: 16.2ºC(lit.)
• 分子式: C₄H₇ClO₄S
• 分子量: 186.614
• 闪点: 101.5±22.6 °C
• 精确质量: 185.975357
• PSA: 68.82000
• LogP: 0.87
• 蒸汽密度: 2.07 (vs air)
• 蒸汽压: 0.0±0.5 mmHg at 25°C
• 折射率: 1.465
• 储存条件: -196°C

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Chlorosulfonyl acetic acid ethyl ester Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Chlorosulfonyl acetic acid ethyl ester CAS number:55896-93-0 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C4H7ClO4S Molecular weight:186.6 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, hydrogen chloride, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): C,Xi
• 风险声明 (欧洲): R34
• 安全声明 (欧洲): 23-26-45
• 危险品运输编码: UN 2790 8/PG 2
• WGK德国: 1
• RTECS号: AF1225000
• 包装等级: III
• 海关编码: 2915900090

合成路线

89124-45-8 ~81% 55896-93-0

文献：InterMune, Inc. Patent: US2009/269305 A1, 2009 ;

22128-42-3 ~92% 55896-93-0

文献：Liu, Yajing; Liu, Zijian; Shi, Jiyue; Chen, Huimin; Mi, Bin; Li, Peng; Gong, Ping Molecules, 2013 , vol. 18, # 3 p. 2864 - 2877

105-39-5 ~59% 55896-93-0

文献：Wolckenhauer, Scott A.; Devlin, A. Sloan; Du Bois Organic Letters, 2007 , vol. 9, # 21 p. 4363 - 4366

623-51-8 ~71% 55896-93-0

文献：Weidner, Karin; Giroult, Andre; Panchaud, Philippe; Renaud, Philippe Journal of the American Chemical Society, 2010 , vol. 132, # 49 p. 17511 - 17515

64-17-5 4025-77-8 ~55% 55896-93-0

文献：Reddy, M. V. Ramana; Mallireddigari, Muralidhar R.; Pallela, Venkat R.; Cosenza, Stephen C.; Billa, Vinay K.; Akula, Balaiah; Subbaiah, D. R. C. Venkata; Bharathi, E. Vijaya; Padgaonkar, Amol; Lv, Hua; Gallo, James M.; Reddy, E. Premkumar Journal of Medicinal Chemistry, 2013 , vol. 56, # 13 p. 5562 - 5586

上下游产品

上游产品  5
89124-45-8 105-39-5 623-51-8 64-17-5
4025-77-8
下游产品  10
75680-93-2 76195-97-6 69579-06-2 658709-20-7
87712-30-9 61154-54-9 61154-55-0 61154-59-4
61154-60-7 61154-66-3

海关

海关编码	2915900090
中文概述	2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验
Summary	2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%