145177-42-0

145177-42-0结构式

常用中文名：GHRP-6 acetate
常用英文名：GHRP-6 acetate
CAS号：145177-42-0
分子式：C₅₂H₆₈N₁₂O₁₂
分子量：1053.17000
发布时间：2016-02-06 18:07:22
更新时间：2024-02-05 04:36:02
GHRP-6 acetate is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It inhibits binding of the GHS-R agonist MK-0677 (Ibutamoren) to COS-7 cell membranes expressing human GHS-R type Ia and binding of ghrelin to COS-7 cells expressing human GHS-R. GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor and inositol phosphate production in COS-7 cells expressing the human receptor. It also acts as a negative allosteric modulator of ghrelin signaling. GHRP-6 induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland. It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.

英文名	acetic acid,(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
英文别名	L-Lysinamide,L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-,triacetate His-D-trp-ala-trp-D-phe-lys-NH2 acetate UNII-USP2MY0E7I Growth hormone releasing hexapeptide acetate