20562-03-2

• 常用中文名：α-卡茄碱
• 常用英文名：alpha-Chaconine
• CAS号：20562-03-2
• 分子式：C₄₅H₇₃NO₁₄
• 分子量：852.05900
• 相关类别： 天然产物 生物碱
• 发布时间：2018-04-23 08:00:00
• 更新时间：2024-01-11 12:25:26
• α-Chaconine,从Solanum tuberosum L. cv Jayoung 分离的,可在转录水平抑制 COX-2,IL-1β,IL-6 和 TNF-α 表达。α-Chaconine 作用于 RAW 264.7 巨噬细胞,在蛋白和 mRNA 水平上抑制 LPS 诱导的 iNOS 和 COX-2 表达及其启动子活性。α-Chaconine 具有抗炎作用。

名称

• 中文名: 卡茄碱
• 英文名: α-CHACONINE
• 英文别名: chaconine; chaconine,a; a-chaconine with tlc; a-chaconine; a-chaconine from potato sprouts; alpa-chaconine

物化性质

• 密度: 1.37 g/cm3
• 熔点: 228-236ºC
• 分子式: C₄₅H₇₃NO₁₄
• 分子量: 852.05900
• 精确质量: 851.50300
• PSA: 220.46000
• LogP: 1.12070
• 折射率: 1.621
• 储存条件: 库房低温通风干燥,与食品原料分开存放
• 水溶解性: pyridine: 10 mg/mL, clear, very faintly yellow

生物活性

• 描述: α-Chaconine,从Solanum tuberosum L. cv Jayoung 分离的,可在转录水平抑制 COX-2,IL-1β,IL-6 和 TNF-α 表达。α-Chaconine 作用于 RAW 264.7 巨噬细胞,在蛋白和 mRNA 水平上抑制 LPS 诱导的 iNOS 和 COX-2 表达及其启动子活性。α-Chaconine 具有抗炎作用。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 靶点:

  COX-2

• 体外研究: α-查康宁通过减少c-jun的易位和磷酸化来减弱激活蛋白-1(AP-1)的转录活性。α-查康碱通过脂多糖诱导的264.7巨噬细胞中的AP-1失活抑制脂多糖诱导的炎症介质,并保护小鼠免受内毒素休克。α- Chaconine也抑制了位于MKK7/JNK信号上游的TGF-β激活激酶-1(TAK1)的磷酸化[1]。
• 参考文献:

  [1]. Lee KG, et al. α-Chaconine isolated from a Solanum tuberosum L. cv Jayoung suppresses lipopolysaccharide-induced pro-inflammatory mediators via AP-1 inactivation in RAW 264.7 macrophages and protects mice from endotoxin shock. Chem Biol Interact. 2015 Jun 25;235:85-94.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : FL6700000 CHEMICAL NAME : alpha-Chaconine CAS REGISTRY NUMBER : 20562-03-2 BEILSTEIN REFERENCE NO. : 0077396 LAST UPDATED : 199612 DATA ITEMS CITED : 10 MOLECULAR FORMULA : C45-H73-N-O14 MOLECULAR WEIGHT : 852.19 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Blood - hemorrhage TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 19 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 160 mg/kg/8D-I TOXIC EFFECTS : Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 80 mg/kg/2D-I TOXIC EFFECTS : Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 40 mg/kg SEX/DURATION : female 5-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 20 mg/kg SEX/DURATION : female 5-12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 165 mg/kg SEX/DURATION : female 8 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 90 mg/kg/3D (Continuous) REFERENCE : FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 33,191,1995 *** REVIEWS *** TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,61,1979

安全

• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R63
• 安全声明 (欧洲): 22-36/37
• 危险品运输编码: UN 1544
• WGK德国: 3
• RTECS号: FL6700000
• 包装等级: III
• 危险类别: 6.1(b)