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66778-36-7价格

66778-36-7

66778-36-7结构式
66778-36-7结构式

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中文名 (±)-4-甲氧基-N-[2-[2-(1-甲基-2-哌啶基)乙基]苯基]苯甲酰胺
英文名 encainide
中文别名 4-甲氧基-N-(2-(2-(1-甲基哌啶-2-基)乙基)苯基)苯甲酰胺
英文别名 MJ-9067[AS BASE]
MJ-9067
Enkaid
Encainida [spanish]
M-9067-1
4-methoxy-N-<2-<2-(1-methyl-2-piperidinyl)ethyl>phenyl>benzamide
Encainide [french]
Encainidum
Enkade
[14C]-Encainide
Encainida
(-)-Encainide
BENZAMIDE, 4-METHOXY-N-[2-[2-(1-METHYL-2-PIPERIDINYL)ETHYL]PHENYL]-
4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide
描述 Encainide(MJ9067)是一种具有ⅠC活动。Encainide有可能用于威胁生命的室性心律失常、症状性室性心律失常和室上性心律失常的研究[1]。
相关类别
体内研究 恩卡肽(0.3,0.9,2.7 mg/kg;单剂量输注)可延长其浦肯野传导时间(HV间期)和心室内传导时间(QRS持续时间),但对窦房结恢复时间或房室结传导,或心房、房室结或心室心肌的难治性或QT间期无影响[1]。
参考文献

[1]. R N Brogden, et al. Encainide. A review of its pharmacological properties and therapeutic efficacy. Drugs. 1987 Nov;34(5):519-38.

分子式 C22H28N2O2
分子量 352.47000
精确质量 352.21500
PSA 41.57000
LogP 4.37530

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV5521000
CHEMICAL NAME :
Benzamide, 4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)pheny l)-, (+-)-
CAS REGISTRY NUMBER :
66778-36-7
BEILSTEIN REFERENCE NO. :
0497572
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C22-H28-N2-O2
MOLECULAR WEIGHT :
352.52

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
3289 ug/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction) Cardiac - change in rate
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 21,998,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP Vascular - BP lowering not characterized in autonomic section
REFERENCE :
AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave., New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,878,1986
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
3214 mg/kg/19H
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
2400 ug/kg/17H
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1500 ug/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year: 102,857,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 281,277,1986