25249-54-1

• 常用中文名：交联聚维酮
• 常用英文名：Polyvinylpyrrolidone cross-linked
• CAS号：25249-54-1
• 分子式：(C₆H₉NO)n
• 分子量：111.142
• 相关类别： 食品添加剂 稳定和凝固剂
• 发布时间：2018-02-05 08:00:00
• 更新时间：2024-01-02 20:29:23

• 1)由于交联聚维酮的高分子量和交联结构，不溶于水但遇水能迅促使其网络结构膨胀并产生崩解作用，医药上广泛用作片剂的崩解剂，另外被广泛用作悬浮稳定剂，药物成分络合剂，植物性药物中单宁及多酚物质的络合剂。

  2)交联聚乙烯基吡咯烷酮(PVP-P)能和酚、生物碱形成复合物，从而从植物样品中把他们去除，这样就阻止了对蛋白的修饰和和干涉，以便更准确地测定蛋白质的含量。也有报道交联聚乙烯基吡咯烷酮(PVP-P)能提高酶的活力。

名称

• 中文名: 交联聚乙烯基吡咯烷酮
• 英文名: 1-ethenylpyrrolidin-2-one
• 中文别名: 交联聚乙烯吡咯烷酮; 交联聚维酮; 聚乙烯聚吡咯烷酮交联; PVP-P(交联聚合物)
• 英文别名: Pvpp; 2-Pyrrolidinone, 1-ethenyl-; N-Vinylpyrrolidinone; vinyl pyrrolidone; Polyvidone; Poly(vinylpolypyrrolidone); N-vinylpyrrolidone; 2-Pyrrolidinone,1-ethenyl; 1-Ethenyl-2-pyrrolidinone (9CI); 1-vinylpyrrolidin-2-one; Polyvinylpyrrolidone; 1-Vinyl-2-pyrrolidinone; N-Vinyl-2-pyrrolidone; crospovidone; MFCD00149016; N-Vinyl pyrrolidone; Povidone; polyvinylpolypyrrolidone; 1-ethenylpyrrolidin-2-one; vinylpyrrolidone; N-VINYL-2-PYRROLIDINONE; Polyvinylpyrrolidone (PVP-P); 1-Vinyl-2-pyrrolidone; Polyvinylpyrrolidone cross-linked

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 217.6±7.0 °C at 760 mmHg
• 熔点: ~165 °C (dec.)(lit.)
• 分子式: (C₆H₉NO)n
• 分子量: 111.142
• 闪点: 93.9±0.0 °C
• 精确质量: 111.068413
• PSA: 20.31000
• LogP: 0.37
• 外观性状: powder | White to off-white
• 蒸汽压: 0.1±0.4 mmHg at 25°C
• 折射率: 1.593
• 储存条件:

  保持贮藏器密封

  放入紧密的贮藏器内，储存在阴凉，干燥的地方

• 稳定性:

  如果遵照规格使用和储存则不会分解

  避免接触氧化物
• 水溶解性: Insoluble in water, acid and alkaline.
• 计算化学:

  1、 疏水参数计算参考值（XlogP）：0.4

  2、 氢键供体数量：0

  3、 氢键受体数量：1

  4、 可旋转化学键数量：1

  5、 互变异构体数量：2

  6、 拓扑分子极性表面积（TPSA）：20.3

  7、 重原子数：8

  8、 表面电荷：0

  9、 复杂度：120

  10、 同位素原子数量：0

  11、 确定原子立构中心数量：0

  12、 不确定原子立构中心数量：0

  13、 确定化学键立构中心数量：0

  14、 不确定化学键立构中心数量：0

  15、 共价键单元数量：1

• 更多:

  1. 性状：白色或近白色，具有吸湿性易流动的粉末，无臭或微臭

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：300

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kpa,20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：不溶于水、碱、酸及常用有机溶剂

MSDS

Name: Polyvinylpyrrolidone cross-linked Material Safety Data Sheet Synonym: Polyvinylpolypyrrolidone; PV CAS: 25249-54-1 Section 1 - Chemical Product MSDS Name:Polyvinylpyrrolidone cross-linked Material Safety Data Sheet Synonym:Polyvinylpolypyrrolidone; PV Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 25249-54-1 Polyvinylpyrrolidone, cross-linked 100 unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Cover with dry earth, dry sand, or other non-combustible material followed with plastic sheet to minimize spreading and contact with water. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 25249-54-1: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: Off-White Micro-Crystalline Powder Odor: None reported. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: > 300 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: Molecular Weight: Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, strong oxidants. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 25249-54-1 unlisted. LD50/LC50: Not available. Carcinogenicity: Polyvinylpyrrolidone, cross-linked - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 25249-54-1: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 25249-54-1 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 25249-54-1 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

生态学数据: 对水是稍微危害的，若无政府许可，勿将材料排入周围环境。

安全

• 安全声明 (欧洲): 22-24/25
• WGK德国: 1
• RTECS号: TR8370000
• 海关编码: 39059900