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上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：2-([11'-联苯]-4-基)-N-(吡啶-2-基)乙酰胺
纯度：97.0%
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51484-40-3生产厂家

51484-40-3价格

51484-40-3

51484-40-3结构式

常用中文名：2-([1,1'-联苯]-4-基)-N-(吡啶-2-基)乙酰胺
常用英文名：[1,1'-Biphenyl]-4-acetamide,N-2-pyridinyl-
CAS号：51484-40-3
分子式：C₁₉H₁₆N₂O
分子量：288.34300
相关类别：研究领域炎症/免疫
发布时间：2018-05-04 08:00:00
更新时间：2024-01-09 16:02:53
二苯吡酰胺(Z-876)是一种双苯乙醇衍生物,具有显著的抗炎、镇痛、解热和尿酸特性。二苯吡酰胺具有抗血小板聚集活性[1]。

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中文名	联苯吡胺
英文名	difenpiramide
英文别名	Z-876 2-Biphenylyl-N-pyridylacetamide 2-(4-phenylphenyl)-N-pyridin-2-ylacetamide Pyridyl-biphenylyl-acetamide Difenax Acetamide,2-biphenylyl-N-pyridyl Difenpiramide Diphenpyramide

描述	二苯吡酰胺(Z-876)是一种双苯乙醇衍生物,具有显著的抗炎、镇痛、解热和尿酸特性。二苯吡酰胺具有抗血小板聚集活性[1]。
相关类别	信号通路 >> 其他 >> 其他研究领域 >> 炎症/免疫
参考文献	[1]. Caliari S, et al. Pharmacological properties of the anti-inflammatory agent pyridyl-biphenylyl-acetamide (diphenpyramide). Arzneimittelforschung. 1977;27(11):2086-2093. [2]. Gugliotta L, et al. Farmaci antiinfiammatori e attività antiaggregante piastrinica: la difenpiramide [Anti-inflammatory drugs and platelet anti-aggregation activity: difenpiramide]. G Clin Med. 1976;57(11-12):408-415.

密度	1.192g/cm3
沸点	549ºC at 760 mmHg
分子式	C₁₉H₁₆N₂O
分子量	288.34300
闪点	285.8ºC
精确质量	288.12600
PSA	41.99000
LogP	4.00280
折射率	1.645
储存条件	室温

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB4549000

CHEMICAL NAME :: Acetamide, 2-biphenylyl-N-pyridyl-

CAS REGISTRY NUMBER :: 51484-40-3

BEILSTEIN REFERENCE NO. :: 0483768

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H16-N2-O

MOLECULAR WEIGHT :: 288.37

WISWESSER LINE NOTATION :: T6NJ BMV1R DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1857 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1396 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2590 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1471 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 118,729,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 118,729,1979

海关编码	2933399090

海关编码	2933399090
中文概述	2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%